CARCAINIUM CHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H22N3O2.Cl
Molecular Weight	347.839
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Cl-].C[N+](C)(CC(=O)NC1=CC=CC=C1)CC(=O)NC2=CC=CC=C2

InChI

InChIKey=YGCONRRHHMKQRL-UHFFFAOYSA-N

InChI=1S/C18H21N3O2.ClH/c1-21(2,13-17(22)19-15-9-5-3-6-10-15)14-18(23)20-16-11-7-4-8-12-16;/h3-12H,13-14H2,1-2H3,(H-,19,20,22,23);1H

HIDE SMILES / InChI

Molecular Formula	C18H22N3O2
Molecular Weight	312.3862
Charge	1
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27538683 | https://www.ncbi.nlm.nih.gov/pubmed/14319089 | https://www.ncbi.nlm.nih.gov/pubmed/12569065

Carcainium is phenylcarbamoylmethyl derivative with local anesthetic and potent anti-tussive activity. In preclinical studies Carcainium significantly reduced the spontaneous and histamine-evoked discharges in Aδ-fibres originating from airway, rapidly adapting stretch receptors (RARs) without affecting histamine-evoked bronchoconstriction. Acute pre-treatment of guinea-pigs with aerosols of Carcainium prevent of capsaicin-evoked and citric acid-induced coughs.

Originator

Approval Year

PubMed

Title	Date	PubMed
RSD931, a novel anti-tussive agent acting on airway sensory nerves.	2003 Feb	12569065

Patents

Sample Use Guides

In Vivo Use Guide

2-8 mg./kg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 04:54:43 GMT 2023` Edited by `admin` on `Sat Dec 16 04:54:43 GMT 2023`
Record UNII	SM0DJQ1HBT
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CARCAINIUM CHLORIDE

Official Name

English

QX-572

Code

English

DIMETHYLBIS((PHENYLCARBAMOYL)METHYL)AMMONIUM CHLORIDE

Systematic Name

English

ETHANAMINIUM, N,N-DIMETHYL-2-OXO-N-(2-OXO-2-(PHENYLAMINO)ETHYL)-2-(PHENYLAMINO)-, CHLORIDE (1:1)

Systematic Name

English

RSD-931

Code

English

carcainium chloride [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47793