U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 17:29:01 GMT 2023
Edited
by admin
on Sat Dec 16 17:29:01 GMT 2023
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG1
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
SM01RRU9KK
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ROMLUSEVIMAB
INN   USAN  
Official Name English
ROMLUSEVIMAB [USAN]
Common Name English
BRII-198
Code English
IMMUNOGLOBULIN G1-LAMBDA2, ANTI-SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS (SARS-COV) (SPIKE GLYCOPROTEIN (PEPLOMER PROTEIN)); HOMO SAPIENS MONOCLONAL ANTIBODY; .GAMMA.1 HEAVY CHAIN HOMO SAPIENS (1-448) (VH (HOMO SAPIENS IGHV7-4-1*02 (96%)-(IGHD)-IGHJ
Common Name English
romlusevimab [INN]
Common Name English
BRII 198 [WHO-DD]
Common Name English
IMMUNOGLOBULIN G1-LAMBDA2, ANTI-(SEVERE ACUTE RESPIRATORYSYNDROME CORONAVIRUS 2 (SARS-COV-2) SPIKE (S) GLYCOPROTEIN,RECEPTOR BINDING DOMAIN (RBD)), HOMO SAPIENS MONOCLONALANTIBODY
Common Name English
BRII198
Code English
Code System Code Type Description
FDA UNII
SM01RRU9KK
Created by admin on Sat Dec 16 17:29:01 GMT 2023 , Edited by admin on Sat Dec 16 17:29:01 GMT 2023
PRIMARY
USAN
JK-256
Created by admin on Sat Dec 16 17:29:01 GMT 2023 , Edited by admin on Sat Dec 16 17:29:01 GMT 2023
PRIMARY
INN
11992
Created by admin on Sat Dec 16 17:29:01 GMT 2023 , Edited by admin on Sat Dec 16 17:29:01 GMT 2023
PRIMARY
SMS_ID
300000026355
Created by admin on Sat Dec 16 17:29:01 GMT 2023 , Edited by admin on Sat Dec 16 17:29:01 GMT 2023
PRIMARY
CAS
2509447-08-7
Created by admin on Sat Dec 16 17:29:01 GMT 2023 , Edited by admin on Sat Dec 16 17:29:01 GMT 2023
PRIMARY
NCI_THESAURUS
C175226
Created by admin on Sat Dec 16 17:29:01 GMT 2023 , Edited by admin on Sat Dec 16 17:29:01 GMT 2023
PRIMARY
From To
1_22 1_96
2_22 2_96
2_146 2_202
2_222 4_213
2_263 2_323
1_146 1_202
2_369 2_427
3_22 3_87
3_136 3_195
4_22 4_87
4_136 4_195
1_222 3_213
1_228 2_228
1_231 2_231
1_263 1_323
1_369 1_427
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_299
N 2_299
Related Record Type Details
TARGET -> INHIBITOR
BRII-198 has no or moderately reduced binding activity (approximately two to three-fold) to human Fc receptors (FcR I, FcR IIa, FcR IIb, FcR IIIa.
BINDING
TARGET ORGANISM->INHIBITOR
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL