Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C19H21NO5S |
| Molecular Weight | 375.439 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=C(C2CC(=NCCS2)C3=C(O)C=C(C)OC3=O)C(OC)=C1
InChI
InChIKey=NHFIAAAMCYVRIW-UHFFFAOYSA-N
InChI=1S/C19H21NO5S/c1-11-8-15(21)18(19(22)25-11)14-10-17(26-7-6-20-14)13-5-4-12(23-2)9-16(13)24-3/h4-5,8-9,17,21H,6-7,10H2,1-3H3
| Molecular Formula | C19H21NO5S |
| Molecular Weight | 375.439 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
KF-38789 is a selective inhibitor of P-selectin-mediated cell adhesion (IC50 = 1.97 uM) that displays no effects on L-selectin- and E-selectin-mediated adhesion. KF-38789 inhibits P-selectin-dependent
cell adhesion, superoxide production by
human PMN and TG-induced cell migration into the murine
peritoneal cavity. It was also identified as a tubulin disruptor.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Vacuolin-1 inhibits autophagy by impairing lysosomal maturation via PIKfyve inhibition. | 2016-06 |
|
| Global gene expression analysis in the mouse brainstem after hyperalgesia induced by facial carrageenan injection--evidence for a form of neurovascular coupling? | 2009-03 |
|
| Inhibition of P-selectin specific cell adhesion by a low molecular weight, non-carbohydrate compound, KF38789. | 2001-11 |
Patents
Sample Use Guides
Mice: KF-38789 (1 mg/kg) was injected intravenously prior to TG injection and at 3 h following initial injection. Intravenously injected KF-38789 significantly inhibited the TG-induced accumulation of leukocytes in the mouse peritoneal cavity.
Route of Administration:
Intravenous
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 23:34:10 GMT 2025
by
admin
on
Mon Mar 31 23:34:10 GMT 2025
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| Record UNII |
SD6U8X7NAE
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| Record Status |
Validated (UNII)
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257292-29-8
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135400439
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