BESIFOVIR DIPIVOXIL

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H34N5O8P
Molecular Weight	527.5078
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(C)C(=O)OCOP(=O)(COC3(CN1C=NC2=CN=C(N)N=C12)CC3)OCOC(=O)C(C)(C)C

InChI

InChIKey=JLKJXDOWBVVABZ-UHFFFAOYSA-N

InChI=1S/C22H34N5O8P/c1-20(2,3)17(28)31-12-34-36(30,35-13-32-18(29)21(4,5)6)14-33-22(7-8-22)10-27-11-25-15-9-24-19(23)26-16(15)27/h9,11H,7-8,10,12-14H2,1-6H3,(H2,23,24,26)

HIDE SMILES / InChI

Molecular Formula	C22H34N5O8P
Molecular Weight	527.5078
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67487369 | https://www.ncbi.nlm.nih.gov/pubmed/18808318

LB80380 is a prodrug of besifovir, a novel antiviral agent for the treatment of chronic hepatitis B.

Originator

Approval Year

PubMed

Title	Date	PubMed
A randomized placebo-controlled, dose-finding study of oral LB80380 in HBeAg-positive patients with chronic hepatitis B.	2006	17302367

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:29:15 GMT 2023` Edited by `admin` on `Fri Dec 15 16:29:15 GMT 2023`
Record UNII	S9I9P4J8IU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BESIFOVIR DIPIVOXIL

Common Name

English

PROPANOIC ACID, 2,2-DIMETHYL-, 1,1'-(((((1-((2-AMINO-9H-PURIN-9-YL)METHYL)CYCLOPROPYL)OXY)METHYL)PHOSPHINYLIDENE)BIS(OXYMETHYLENE)) ESTER

Common Name

English

LB-80380

Code

English

PROPANOIC ACID, 2,2-DIMETHYL-, ((((1-((2-AMINO-9H-PURIN-9-YL)METHYL)CYCLOPROPYL)OXY)METHYL)PHOSPHINYLIDENE)BIS(OXYMETHYLENE) ESTER

Common Name

English

LB80380

Common Name

English

PMCDG DIPIVOXIL

Common Name

English

AN-380

Common Name

English

9-(1-(PHOSPHONOMETHOXYCYCLOPROPYL)METHYL)-6-DEOXYGUANINE DIPIVOXIL

Common Name

English

LB 80380

Code

English

Code System Code Type Description

FDA UNII

S9I9P4J8IU