Details
| Stereochemistry | UNKNOWN |
| Molecular Formula | C19H23ClN2 |
| Molecular Weight | 314.852 |
| Optical Activity | ( - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1CCCN(CC1)C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3
InChI
InChIKey=WEUCDJCFJHYFRL-UHFFFAOYSA-N
InChI=1S/C19H23ClN2/c1-21-12-5-13-22(15-14-21)19(16-6-3-2-4-7-16)17-8-10-18(20)11-9-17/h2-4,6-11,19H,5,12-15H2,1H3
| Molecular Formula | C19H23ClN2 |
| Molecular Weight | 314.852 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
DescriptionCurator's Comment: description was created based on several sources, including
http://www.eisai.jp/medical/products/di/EPI/HC_T_EPI.pdf
Curator's Comment: description was created based on several sources, including
http://www.eisai.jp/medical/products/di/EPI/HC_T_EPI.pdf
Homochlorcyclizine (INN) is an antihistamine which has been marketed in Japan since 1965. It is used in the treatment of Itching sensation resulting from skin diseases (eczema or dermatitis, pruritus, drug eruption, toxic erythema and infant strophulus), urticaria and allergic rhinitis. Homochlorcyclizine hydrochloride possesses several pharmacological properties: 1) inhibits bradykinin-induced contractions of isolated guinea pig ileum; 2)partially blocks SRS-A (slow-reacting substance of anaphylaxis )- induced contractions in isolated guinea pig il eum. 3) Homochlorcyclizine hydrochloride completely inhibits histamine-induced contractions at a concentration of 0.1μg/mL, while it completely inhibits serotonin or acetylcholine- induced contractions at a concentration of 1μg/mL.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. | 2011-07-14 |
|
| Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method. | 2010-12 |
|
| A similarity search using molecular topological graphs. | 2009 |
|
| Simultaneous determination of ten antihistamine drugs in human plasma using pipette tip solid-phase extraction and gas chromatography/mass spectrometry. | 2006 |
|
| Effect of (+) or (-) camphorsulfonic acid additives to the mobile phase on enantioseparations of some basic drugs on a Chiralcel OD column. | 2005-08-12 |
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| Histamine H1-receptor antagonists, promethazine and homochlorcyclizine, increase the steady-state plasma concentrations of haloperidol and reduced haloperidol. | 2003-04 |
|
| Role of mast cell chymase in allergen-induced biphasic skin reaction. | 2002-10-01 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 23:23:12 GMT 2025
by
admin
on
Mon Mar 31 23:23:12 GMT 2025
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| Record UNII |
S8XST56UYL
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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Preferred Name | English | ||
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Systematic Name | English |
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142860-97-7
Created by
admin on Mon Mar 31 23:23:12 GMT 2025 , Edited by admin on Mon Mar 31 23:23:12 GMT 2025
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PRIMARY | |||
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S8XST56UYL
Created by
admin on Mon Mar 31 23:23:12 GMT 2025 , Edited by admin on Mon Mar 31 23:23:12 GMT 2025
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PRIMARY |