Details
| Stereochemistry | UNKNOWN |
| Molecular Formula | C19H23ClN2 |
| Molecular Weight | 314.852 |
| Optical Activity | ( - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1CCCN(CC1)C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3
InChI
InChIKey=WEUCDJCFJHYFRL-UHFFFAOYSA-N
InChI=1S/C19H23ClN2/c1-21-12-5-13-22(15-14-21)19(16-6-3-2-4-7-16)17-8-10-18(20)11-9-17/h2-4,6-11,19H,5,12-15H2,1H3
| Molecular Formula | C19H23ClN2 |
| Molecular Weight | 314.852 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
DescriptionCurator's Comment: description was created based on several sources, including
http://www.eisai.jp/medical/products/di/EPI/HC_T_EPI.pdf
Curator's Comment: description was created based on several sources, including
http://www.eisai.jp/medical/products/di/EPI/HC_T_EPI.pdf
Homochlorcyclizine (INN) is an antihistamine which has been marketed in Japan since 1965. It is used in the treatment of Itching sensation resulting from skin diseases (eczema or dermatitis, pruritus, drug eruption, toxic erythema and infant strophulus), urticaria and allergic rhinitis. Homochlorcyclizine hydrochloride possesses several pharmacological properties: 1) inhibits bradykinin-induced contractions of isolated guinea pig ileum; 2)partially blocks SRS-A (slow-reacting substance of anaphylaxis )- induced contractions in isolated guinea pig il eum. 3) Homochlorcyclizine hydrochloride completely inhibits histamine-induced contractions at a concentration of 0.1μg/mL, while it completely inhibits serotonin or acetylcholine- induced contractions at a concentration of 1μg/mL.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Histamine H1-receptor antagonists, promethazine and homochlorcyclizine, increase the steady-state plasma concentrations of haloperidol and reduced haloperidol. | 2003 Apr |
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| Simultaneous determination of ten antihistamine drugs in human plasma using pipette tip solid-phase extraction and gas chromatography/mass spectrometry. | 2006 |
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| A similarity search using molecular topological graphs. | 2009 |
|
| Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method. | 2010 Dec |
|
| Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. | 2011 Jul 14 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:40:48 GMT 2023
by
admin
on
Sat Dec 16 10:40:48 GMT 2023
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| Record UNII |
S8XST56UYL
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| Record Status |
Validated (UNII)
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| Record Version |
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142860-97-7
Created by
admin on Sat Dec 16 10:40:48 GMT 2023 , Edited by admin on Sat Dec 16 10:40:48 GMT 2023
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S8XST56UYL
Created by
admin on Sat Dec 16 10:40:48 GMT 2023 , Edited by admin on Sat Dec 16 10:40:48 GMT 2023
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PRIMARY |