MAGNESIUM L-GLUTAMATE TETRAHYDRATE

Possibly Marketed Outside US

Details

Stereochemistry	ABSOLUTE
Molecular Formula	2C5H7NO4.Mg.2H.4H2O
Molecular Weight	388.6088
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MAGNESIUM L-GLUTAMATE TETRAHYDRATE

Structure Search

SMILES

[H+].[H+].O.O.O.O.[Mg++].N[C@@H](CCC([O-])=O)C([O-])=O.N[C@@H](CCC([O-])=O)C([O-])=O

InChI

InChIKey=ZWCGDRSVJYJGFY-GYDBBPQESA-L

InChI=1S/2C5H9NO4.Mg.4H2O/c2*6-3(5(9)10)1-2-4(7)8;;;;;/h2*3H,1-2,6H2,(H,7,8)(H,9,10);;4*1H2/q;;+2;;;;/p-2/t2*3-;;;;;/m00...../s1

HIDE SMILES / InChI

Molecular Formula	H2O
Molecular Weight	18.0153
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C5H9NO4
Molecular Weight	147.1293
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	Mg
Molecular Weight	24.305
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://noshly.com/additive/e625/flavour-enhancer/625/ | http://www.thegoodscentscompany.com/data/rw1609401.html | http://www.foodadditiveslist.com/page/55/ | http://www.fao.org/ag/agn/jecfa-additives/specs/Monograph1/Additive-259.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/680616 | http://www.druginfosys.com/drug.aspx?drugcode=1321&type=1

Magnesium glutamate hydrobromide (Psychoverlan) is a known sedative and muscle relaxant. In a long-term study 19 young females were treated with Psychoverlan capsules or syrup for an average of 11.4 months. Intolerance phenomena and side-effects were not seen. It was even decided to increase the standard dose. None of the patients developed brominism or bromine intoxication. The general state of health of 13 of the 19 subjects was improved by the harmonizing effect of the drug on psychic and vegetative functions. Tiredness and somnolence were not observed.

CNS Activity

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Psychotic disorder 26 Sources: https://www.ncbi.nlm.nih.gov/pubmed/680616 https://www.ncbi.nlm.nih.gov/pubmed/4849930	Primary		Approved 8583	PSYCHOVERLAN Approved Use Nervous system disorders
Unknown 2596

PubMed

Title	Date	PubMed
Synthesis and biological evaluation of (-)-6-O-desmethylcryptopleurine and analogs.	2015-01-15	25499434
No enhancing effects of calcium/magnesium salts of L-glutamate and L-ascorbate on tumor development in a rat medium-term multiorgan carcinogenesis bioassay.	1993-05	8492329
[Long-term treatment with psychoverlan in children and adolescents with behavior disorders].	1978-08-24	680616
[The management of nervous disturbances with psychoverlan].	1974-05	4849930

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Oral

In Vitro Use Guide

60 g (0.160 mol) magnesium-L-glutamate-tetrahydrate in a spherical flask were suhmerged in the rotary evaporator under a vacuum of 50 mbar in an oil bath that had been preheated to 190C. The separation of water and the formation of the magnesium-L-pyroglutamate began after 2 minutes and ended after 45 minutes, a solid being involved at each stage of the reaction.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 23:05:22 GMT 2025` Edited by `admin` on `Mon Mar 31 23:05:22 GMT 2025`
Record UNII	S8TL3KXK0I
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

L-GLUTAMIC ACID, MAGNESIUM SALT (2:1), TETRAHYDRATE

Preferred Name

English

MAGNESIUM L-GLUTAMATE TETRAHYDRATE

Systematic Name

English

MAGNESATE(2-), BIS(L-GLUTAMATO(2-)-N,O1)-, DIHYDROGEN, TETRAHYDRATE, (T-4)-

Systematic Name

English

MAGNESIUM DI-L-GLUTAMATE

Systematic Name

English

Code System Code Type Description

CODEX ALIMENTARIUS (GSFA)

INS-626