Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C2H4N2.ClH |
| Molecular Weight | 92.528 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.NCC#N
InChI
InChIKey=XFKYKTBPRBZDFG-UHFFFAOYSA-N
InChI=1S/C2H4N2.ClH/c3-1-2-4;/h1,3H2;1H
| Molecular Formula | C2H4N2 |
| Molecular Weight | 56.0666 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Oral supplementation with Leu-Ile, a hydrophobic dipeptide, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of extracellular signal-regulated kinase. | 2010-07-11 |
|
| Intrastriatal inhibition of extracellular signal-regulated kinases impaired the consolidation phase of motor skill learning. | 2010-07 |
|
| Quarantine treatment of sheep with monepantel--rapidity of fecal egg count reduction. | 2010-06-24 |
|
| Slipped capital femoral epiphysis: an ultrastructural study before and after osteosynthesis. | 2010-06 |
|
| The control of inhibited fourth-stage larvae of Haemonchus contortus and Teladorsagia spp. in sheep in Australia with monepantel. | 2010-05-11 |
|
| Effect of route of administration on the efficacy and pharmacokinetics of an experimental formulation of the amino-acetonitrile derivative monepantel in sheep. | 2010-04-17 |
|
| Use of monepantel. | 2010-04-10 |
|
| Regulation of plant glycine decarboxylase by s-nitrosylation and glutathionylation. | 2010-03 |
|
| Tholinomics--chemical analysis of nitrogen-rich polymers. | 2010-02-15 |
|
| Identification of plasticity-associated genes regulated by Pavlovian fear conditioning in the lateral amygdala. | 2010-02 |
|
| [Determination of streptomycin in honey determined by hydrophilic interaction chromatography combined with tandem mass spectrometry]. | 2010-01 |
|
| The effect of sheep breed, age, and gender on the pharmacokinetics and efficacy of monepantel, an amino-acetonitrile derivative. | 2010-01 |
|
| A pooled analysis of the efficacy of monepantel, an amino-acetonitrile derivative against gastrointestinal nematodes of sheep. | 2010-01 |
|
| The time course of unconditioned morphine-induced psychomotor sensitization mirrors the phosphorylation of FADD and MEK/ERK in rat striatum: role of PEA-15 as a FADD-ERK binding partner in striatal plasticity. | 2010-01 |
|
| Deep-space glycine formation via Strecker-type reactions activated by ice water dust mantles. A computational approach. | 2010 |
|
| The efficacy of monepantel, an amino-acetonitrile derivative, against gastrointestinal nematodes of sheep in three countries of southern Latin America. | 2009-12 |
|
| Fustin flavonoid attenuates beta-amyloid (1-42)-induced learning impairment. | 2009-12 |
|
| Synergistic interactions of dopamine D1 and glutamate NMDA receptors in rat hippocampus and prefrontal cortex: involvement of ERK1/2 signaling. | 2009-11-10 |
|
| Cyclocondensation of alpha-aminonitriles and enones: a short access to 3,4-dihydro-2H-pyrrole 2-carbonitriles and 2,3,5-trisubstituted pyrroles. | 2009-11-06 |
|
| Extracellular signal-regulated kinase activation is required for consolidation and reconsolidation of memory at an early stage of ontogenesis. | 2009-11 |
|
| Clinical field study to evaluate the efficacy and safety of the amino-acetonitrile derivative, monepantel, compared with registered anthelmintics against gastrointestinal nematodes of sheep in Australia. | 2009-11 |
|
| Differential involvement of D1 and D2 dopamine receptors in L-DOPA-induced angiogenic activity in a rat model of Parkinson's disease. | 2009-11 |
|
| Reduction of nitrogen compounds in oceanic basement and its implications for HCN formation and abiotic organic synthesis. | 2009-10-22 |
|
| Extracellular signal-regulated kinase activation in the amygdala mediates elevated plus maze behavior during opioid withdrawal. | 2009-10 |
|
| Anthelmintic resistance in cyathostomin populations from horse yards in Italy, United Kingdom and Germany. | 2009-09-25 |
|
| Cross-talk between protein kinase A and mitogen-activated protein kinases signalling in the adaptive changes observed during morphine withdrawal in the heart. | 2009-09 |
|
| Safety of an amino-acetonitrile derivative (AAD), monepantel, in ewes and their offspring following repeated oral administration. | 2009-08 |
|
| Pharmacokinetics of monepantel and its sulfone metabolite, monepantel sulfone, after intravenous and oral administration in sheep. | 2009-08 |
|
| Abstracts of the 2008 ISSOL Meeting. August 24-29, 2008. Florence, Italy. | 2009-08 |
|
| ERK signalling pathway is not involved in PSA-NCAM-dependent alterations of hippocampal plasticity evoked by CB1 receptor activation. | 2009-07-22 |
|
| Effect of fasting sheep for a short period on the efficacy and safety of monepantel. | 2009-07-11 |
|
| The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits. | 2009-07 |
|
| Increased operant responding for ethanol in male C57BL/6J mice: specific regulation by the ERK1/2, but not JNK, MAP kinase pathway. | 2009-05 |
|
| Haemonchus contortus acetylcholine receptors of the DEG-3 subfamily and their role in sensitivity to monepantel. | 2009-04 |
|
| Dose confirmation studies for monepantel, an amino-acetonitrile derivative, against fourth stage gastro-intestinal nematode larvae infecting sheep. | 2009-03-23 |
|
| Determination of the effective dose rate for monepantel (AAD 1566) against adult gastro-intestinal nematodes in sheep. | 2009-03 |
|
| Reproductive safety of an amino-acetonitrile derivative (AAD), monepantel, in rams following repeated oral administration. | 2009-02 |
|
| Safety of an amino-acetonitrile derivative ( AAD ), monepantel, in weaned lambs following repeated oral administration. | 2009-02 |
|
| A large-scale clinical field study to evaluate the efficacy and safety of an oral formulation of the amino-acetonitrile derivative ( AAD ), monepantel , in sheep in New Zealand. | 2009-02 |
|
| Efficacy of the amino-acetonitrile derivative, monepantel, against experimental and natural adult stage gastro-intestinal nematode infections in sheep. | 2009-01-22 |
|
| Effects of the MEK inhibitor, SL-327, on rewarding, motor- and cellular-activating effects of D-amphetamine and SKF-82958, and their augmentation by food restriction in rat. | 2009-01 |
|
| IL-6 mediated alterations on immobile behavior of rats in the forced swim test via ERK1/2 activation in specific brain regions. | 2008-11-21 |
|
| Changes in apical dendritic structure correlate with sustained ERK1/2 phosphorylation in medial prefrontal cortex of a rat model of dopamine D1 receptor agonist sensitization. | 2008-11-10 |
|
| Dose determination studies for monepantel, an amino-acetonitrile derivative, against fourth stage gastro-intestinal nematode larvae infecting sheep. | 2008-10-20 |
|
| Regulation of extracellular signal-regulated kinases (ERKs) by naloxone-induced morphine withdrawal in the brain stress system. | 2008-10 |
|
| Developing novel anthelmintics from plant cysteine proteinases. | 2008-09-01 |
|
| Identification of the amino-acetonitrile derivative monepantel (AAD 1566) as a new anthelmintic drug development candidate. | 2008-09 |
|
| The PKs PKA and ERK 1/2 are involved in phosphorylation of TH at Serine 40 and 31 during morphine withdrawal in rat hearts. | 2008-09 |
|
| Estradiol-induced enhancement of object memory consolidation involves hippocampal extracellular signal-regulated kinase activation and membrane-bound estrogen receptors. | 2008-08-27 |
|
| Discovery of amino-acetonitrile derivatives, a new class of synthetic anthelmintic compounds. | 2008-05-01 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:17:10 GMT 2025
by
admin
on
Mon Mar 31 21:17:10 GMT 2025
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| Record UNII |
S8L3V1KSB7
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| Record Status |
Validated (UNII)
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| Record Version |
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6011-14-9
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227-865-9
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22340
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S8L3V1KSB7
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m1676
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DTXSID10884212
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