FLORIFENINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H22F3N3O2
Molecular Weight	429.4349
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC(F)(F)C1=CC2=NC=CC(NC3=CC=CC=C3C(=O)OCCN4CCCC4)=C2C=C1

InChI

InChIKey=DQOYUDHAZMAVLD-UHFFFAOYSA-N

InChI=1S/C23H22F3N3O2/c24-23(25,26)16-7-8-17-20(9-10-27-21(17)15-16)28-19-6-2-1-5-18(19)22(30)31-14-13-29-11-3-4-12-29/h1-2,5-10,15H,3-4,11-14H2,(H,27,28)

HIDE SMILES / InChI

Molecular Formula	C23H22F3N3O2
Molecular Weight	429.4349
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7609784

FLORIFENINE is an anti-inflammatory agent. It inhibits the cyclooxygenase pathway and, in addition, it inhibits migration and decreases in vitro the release of neutrophil elastase.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
cyclooxygenase pathway 5 Target ID: GO:0019371 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7609784	Inhibitor 8297

PubMed

Title	Date	PubMed
A study of the novel anti-inflammatory agent florifenine topical anti-inflammatory activity and influence on arachidonic acid metabolism and neutrophil functions.	1995 Mar	7609784

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:31:39 UTC 2023` Edited by `admin` on `Sat Dec 16 16:31:39 UTC 2023`
Record UNII	S7UT8VQG94
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLORIFENINE

Official Name

English

florifenine [INN]

Common Name

English

2-(1-PYRROLIDINYL)ETHYL N-(7-(TRIFLUOROMETHYL)-4-QUINOLYL)ANTHRANILATE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C241