Phosphatidylinositol (3,4,5)-trisphosphate

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C47H86O22P4
Molecular Weight	1127.0676
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	4
Charge	0

SHOW SMILES / InChI

Structure of Phosphatidylinositol (3,4,5)-trisphosphate

Structure Search

SMILES

CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)O[C@@H]1[C@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H]1O)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC

InChI

InChIKey=BRGYSCORDHSZEK-WWZVCVIKSA-N

InChI=1S/C47H86O22P4/c1-3-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-36-41(49)65-39(37-63-40(48)35-33-31-29-27-25-23-21-18-16-14-12-10-8-6-4-2)38-64-73(61,62)69-44-42(50)45(66-70(52,53)54)47(68-72(58,59)60)46(43(44)51)67-71(55,56)57/h11,13,17,19,22,24,28,30,39,42-47,50-51H,3-10,12,14-16,18,20-21,23,25-27,29,31-38H2,1-2H3,(H,61,62)(H2,52,53,54)(H2,55,56,57)(H2,58,59,60)/b13-11-,19-17-,24-22-,30-28-/t39-,42+,43+,44-,45+,46-,47-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C47H86O22P4
Molecular Weight	1127.0676
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	4
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Wed Apr 02 20:24:44 GMT 2025` Edited by `admin` on `Wed Apr 02 20:24:44 GMT 2025`
Record UNII	S7U6QTD522
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PIP3

Preferred Name

English

Phosphatidylinositol (3,4,5)-trisphosphate

Common Name

English

PtdIns(3,4,5)P3

Common Name

English

Code System Code Type Description

FDA UNII

S7U6QTD522

Created by admin on Wed Apr 02 20:24:44 GMT 2025 , Edited by admin on Wed Apr 02 20:24:44 GMT 2025

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Related Record Type Details


					HC6J8I9XAO

PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN

METABOLIC ENZYME -> SUBSTRATE

Comments:

Acts as a phosphatase to dephosphorylate PIP3 back to PIP2. This removes the membrane-localization factor from the Akt signaling pathway. Without this localization, the rate of Akt1 activation decreases significantly, as do all of the downstream pathways that depend on Akt1 for activation.

Amount: