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Details

Stereochemistry ACHIRAL
Molecular Formula 3C6H4NO2.Cr
Molecular Weight 418.3005
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CHROMIUM PICOLINATE

SMILES

[Cr+3].[O-]C(=O)C1=NC=CC=C1.[O-]C(=O)C2=NC=CC=C2.[O-]C(=O)C3=NC=CC=C3

InChI

InChIKey=CBDQOLKNTOMMTL-UHFFFAOYSA-K
InChI=1S/3C6H5NO2.Cr/c3*8-6(9)5-3-1-2-4-7-5;/h3*1-4H,(H,8,9);/q;;;+3/p-3

HIDE SMILES / InChI
Molecular Formula Cr
Molecular Weight 51.9961
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C6H4NO2
Molecular Weight 122.1015
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Chromium sulfate(III) hexahydrate or chromium sulphate, a trivalent compound of chromium that was investigated as a toxic compound. Experiments on rodent have shown chromium sulfate produced severe and widespread effects in the nasal cavity, larynx, lungs, and mediastinal lymph node. Effects were characterized by the accumulation of foreign material, infiltration of alveolar macrophages, septal cell hyperplasia, and granulomatous and chronic inflammation. Besides, chromium sulphate exerted a disadvantageous effect on the skeleton, as it decreases bone density and resistance.

Approval Year

1986
103
Targets

Targets

Primary TargetPharmacologyConditionPotency
Activator
1430
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Approved
8429
CHROMIUM

Approved Use

Chromium 4 mcg/mL (Chromic Chloride Injection, USP) is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition. Administration helps to maintain chromium serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.

Launch Date

2005
PubMed

PubMed

TitleDatePubMed
Cytokine induction in human epidermal keratinocytes exposed to contact irritants and its relation to chemical-induced inflammation in mouse skin.
1994 Jun
Silicate antibodies in women with silicone breast implants: development of an assay for detection of humoral immunity.
1996 Mar
Activation of MAPKs in human bronchial epithelial cells exposed to metals.
1998 Sep
Thirteen-week subchronic rat inhalation toxicity study with a recovery phase of trivalent chromium compounds, chromic oxide, and basic chromium sulfate.
1999 Dec
Status of antioxidant defense system in chromium-induced Swiss mice tissues.
2004 Jul
The role of oxidative stress in the modulation of aryl hydrocarbon receptor-regulated genes by As3+, Cd2+, and Cr6+.
2005 Dec 1
Transcriptional activation and posttranscriptional modification of Cyp1a1 by arsenite, cadmium, and chromium.
2007 Aug
Effects of subchronic exposure via drinking water to a mixture of eight water-contaminating metals: a biochemical and histopathological study in male rats.
2007 Nov
Immunosuppressive effect of subchronic exposure to a mixture of eight heavy metals, found as groundwater contaminants in different areas of India, through drinking water in male rats.
2007 Oct
The peripheral quantitative computed tomographic and densitometric analysis of skeletal tissue in male Wistar rats after chromium sulfate treatment.
2017 Sep 21
Patents

Patents

20010006640
24
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:43:04 GMT 2023
Edited
by admin
on Fri Dec 15 15:43:04 GMT 2023
Record UNII
S71T8B8Z6P
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CHROMIUM PICOLINATE
MI   USP-RS   VANDF   WHO-DD  
Systematic Name English
CHROMIUM GTF
Common Name English
CHROMIUM PICOLINATE [USP-RS]
Common Name English
CHROMIUM PICOLINATE [VANDF]
Common Name English
Chromium picolinate [WHO-DD]
Common Name English
CHROMIUM TRIPICOLINATE
MART.  
Systematic Name English
GTF CHROMIUM
Common Name English
CHROMIUM PICOLINATE [MI]
Common Name English
CHROMIUM(III) TRISPICOLINATE
Systematic Name English
CHROMIUM TRIPICOLINATE [MART.]
Common Name English
Classification Tree Code System Code
DSLD 41 (Number of products:6537)
Created by admin on Fri Dec 15 15:43:05 GMT 2023 , Edited by admin on Fri Dec 15 15:43:05 GMT 2023
FDA ORPHAN DRUG 456814
Created by admin on Fri Dec 15 15:43:05 GMT 2023 , Edited by admin on Fri Dec 15 15:43:05 GMT 2023
DSLD 2491 (Number of products:132)
Created by admin on Fri Dec 15 15:43:05 GMT 2023 , Edited by admin on Fri Dec 15 15:43:05 GMT 2023
Code System Code Type Description
FDA UNII
S71T8B8Z6P
Created by admin on Fri Dec 15 15:43:05 GMT 2023 , Edited by admin on Fri Dec 15 15:43:05 GMT 2023
PRIMARY
RS_ITEM_NUM
1133638
Created by admin on Fri Dec 15 15:43:05 GMT 2023 , Edited by admin on Fri Dec 15 15:43:05 GMT 2023
PRIMARY
CAS
14639-25-9
Created by admin on Fri Dec 15 15:43:05 GMT 2023 , Edited by admin on Fri Dec 15 15:43:05 GMT 2023
PRIMARY
NCI_THESAURUS
C28931
Created by admin on Fri Dec 15 15:43:05 GMT 2023 , Edited by admin on Fri Dec 15 15:43:05 GMT 2023
PRIMARY
CHEBI
50369
Created by admin on Fri Dec 15 15:43:05 GMT 2023 , Edited by admin on Fri Dec 15 15:43:05 GMT 2023
PRIMARY
EVMPD
SUB127351
Created by admin on Fri Dec 15 15:43:05 GMT 2023 , Edited by admin on Fri Dec 15 15:43:05 GMT 2023
PRIMARY
DRUG BANK
DB11255
Created by admin on Fri Dec 15 15:43:05 GMT 2023 , Edited by admin on Fri Dec 15 15:43:05 GMT 2023
PRIMARY
EVMPD
SUB13363MIG
Created by admin on Fri Dec 15 15:43:05 GMT 2023 , Edited by admin on Fri Dec 15 15:43:05 GMT 2023
PRIMARY
MERCK INDEX
m3510
Created by admin on Fri Dec 15 15:43:05 GMT 2023 , Edited by admin on Fri Dec 15 15:43:05 GMT 2023
PRIMARY Merck Index
SMS_ID
100000090351
Created by admin on Fri Dec 15 15:43:05 GMT 2023 , Edited by admin on Fri Dec 15 15:43:05 GMT 2023
PRIMARY
DRUG CENTRAL
4511
Created by admin on Fri Dec 15 15:43:05 GMT 2023 , Edited by admin on Fri Dec 15 15:43:05 GMT 2023
PRIMARY
CAS
15713-60-7
Created by admin on Fri Dec 15 15:43:05 GMT 2023 , Edited by admin on Fri Dec 15 15:43:05 GMT 2023
ALTERNATIVE
DAILYMED
S71T8B8Z6P
Created by admin on Fri Dec 15 15:43:05 GMT 2023 , Edited by admin on Fri Dec 15 15:43:05 GMT 2023
PRIMARY
WIKIPEDIA
Chromium(III) picolinate
Created by admin on Fri Dec 15 15:43:05 GMT 2023 , Edited by admin on Fri Dec 15 15:43:05 GMT 2023
PRIMARY
PUBCHEM
151932
Created by admin on Fri Dec 15 15:43:05 GMT 2023 , Edited by admin on Fri Dec 15 15:43:05 GMT 2023
PRIMARY
EPA CompTox
DTXSID1024831
Created by admin on Fri Dec 15 15:43:05 GMT 2023 , Edited by admin on Fri Dec 15 15:43:05 GMT 2023
PRIMARY
NCI_THESAURUS
C1505
Created by admin on Fri Dec 15 15:43:05 GMT 2023 , Edited by admin on Fri Dec 15 15:43:05 GMT 2023
CONCEPT Dietary Supplement
RXCUI
59308
Created by admin on Fri Dec 15 15:43:05 GMT 2023 , Edited by admin on Fri Dec 15 15:43:05 GMT 2023
PRIMARY RxNorm
Related Record Type Details
Structure of PICOLINIC ACID
PARENT -> SALT/SOLVATE
Structure of CHROMIUM PICOLINATE MONOHYDRATE
SOLVATE->ANHYDROUS
Structure of CHROMIC CATION
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of CHROMIC CATION
ACTIVE MOIETY
NIH
NCATS
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ACCESSIBILITY
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