ISRIB

Details

Stereochemistry	RACEMIC
Molecular Formula	C22H24Cl2N2O4
Molecular Weight	451.343
Optical Activity	( + / - )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC1=CC=C(OCC(=O)N[C@H]2CC[C@@H](CC2)NC(=O)COC3=CC=C(Cl)C=C3)C=C1

InChI

InChIKey=HJGMCDHQPXTGAV-IYARVYRRSA-N

InChI=1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2,(H,25,27)(H,26,28)/t17-,18-

HIDE SMILES / InChI

Molecular Formula	C22H24Cl2N2O4
Molecular Weight	451.343
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
response to stress 3 Target ID: GO:0006950 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25719440\| https://www.ncbi.nlm.nih.gov/pubmed/30674674	Inhibitor 8504
Translation initiation factor eIF-2B subunit delta 1 Target ID: Q9UI10 Gene ID: 8890.0 Gene Symbol: EIF2B4 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/29599245	Binding Agent 1076

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:21:59 GMT 2025` Edited by `admin` on `Mon Mar 31 18:21:59 GMT 2025`
Record UNII	S6SZR97SBZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ISRIB

Common Name

English

SMDC-750213

Preferred Name

English

SMDC750213

Systematic Name

English

Acetamide, N,N?-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)-

Systematic Name

English

N,N?-trans-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]

Systematic Name

English

Trans-ISRIB

Common Name

English

Code System Code Type Description

PUBCHEM

1011240