Details
Stereochemistry | ACHIRAL |
Molecular Formula | C6H11N3.2ClH |
Molecular Weight | 198.094 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.CNCCC1=CN=CN1
InChI
InChIKey=AYUQICXJAMPXPF-UHFFFAOYSA-N
InChI=1S/C6H11N3.2ClH/c1-7-3-2-6-4-8-5-9-6;;/h4-5,7H,2-3H2,1H3,(H,8,9);2*1H
Molecular Formula | C6H11N3 |
Molecular Weight | 125.1716 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/24534036
Sources: https://www.ncbi.nlm.nih.gov/pubmed/24534036
alpha-N-methyl-histamine is a metabolite of histamine that plays an important role in several (patho) physiological processes. alpha-N-methyl-histamine is being a potent agonist of histamine H3 receptor can be used as an effective therapeutic alternative in migraine patients.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: Q9QYN8 Gene ID: 85268.0 Gene Symbol: Hrh3 Target Organism: Rattus norvegicus (Rat) Sources: https://www.ncbi.nlm.nih.gov/pubmed/2161226 |
0.4 nM [Kd] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Preventing | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
Characterization and tissue distribution of H3 histamine receptors in guinea pigs by N alpha-methylhistamine. | 1990 May 16 |
|
Systematic analysis of histamine and N-methylhistamine concentrations in organs from two common laboratory mouse strains: C57Bl/6 and Balb/c. | 2011 Dec |
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N alpha methyl histamine versus propranolol in migraine prophylaxis. | 2014 Mar |
|
What a Difference a Methyl Group Makes: The Selectivity of Monoamine Oxidase B Towards Histamine and N-Methylhistamine. | 2017 Feb 24 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/24534036
in migraine prophylaxis: 1 to 3 ug twice a week
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2161226
Unknown
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 01:59:54 GMT 2023
by
admin
on
Sat Dec 16 01:59:54 GMT 2023
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Record UNII |
S6S98U0517
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Record Status |
Validated (UNII)
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Record Version |
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-
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