DOTMP SM-153

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H29N4O12P4.Sm
Molecular Weight	698.1954
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[153Sm+3].OP(O)(=O)CN1CCN(CP(O)([O-])=O)CCN(CP(O)([O-])=O)CCN(CP(O)([O-])=O)CC1

InChI

InChIKey=LNBUCNBAQQFTBL-GJNDDOAHSA-K

InChI=1S/C12H32N4O12P4.Sm/c17-29(18,19)9-13-1-2-14(10-30(20,21)22)5-6-16(12-32(26,27)28)8-7-15(4-3-13)11-31(23,24)25;/h1-12H2,(H2,17,18,19)(H2,20,21,22)(H2,23,24,25)(H2,26,27,28);/q;+3/p-3/i;1+3

HIDE SMILES / InChI

Molecular Formula	Sm
Molecular Weight	152.9221
Charge	3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C12H29N4O12P4
Molecular Weight	545.2733
Charge	-3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/30900619 | https://www.ncbi.nlm.nih.gov/pubmed/28373820

SAMARIUM SM-153 is a β- and γ-emitter with a physical half-life around 46.8 hours. Sm-153 treatment is recommended for patients with multiple bone metastases with the osteoblastic component, regardless of the primary tumor’s location. This compound was used in prostate cancer. It was shown that the small influence of Sm-153 on hematological parameters in patients treated with Sm-153, because of the high affinity of Sm-153 to osteoblastic metastases, and of the effect of low concentration of radionuclide in healthy bone tissue.

Approval Year

PubMed

Title	Date	PubMed
The influence of Sm-153 therapy on bone marrow function.	2016	28373820
Effect of Au-197 nanoparticles along with Sm-153 radiopharmaceutical in prostate cancer from simulation method.	2019 Mar	30900619

Sample Use Guides

In Vivo Use Guide

118 patients received single doses of placebo or Sm-153 of dose 0.5 mCi/kg or 1.0 mCi/kg

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Sat Dec 16 14:39:35 GMT 2023` Edited by `admin` on `Sat Dec 16 14:39:35 GMT 2023`
Record UNII	S5NN2E9ZKF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DOTMP SM-153

Common Name

English

CYCLOSAM

Brand Name

English

SM-153-DOTMP

Common Name

English

153SM-1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10- TETRAMETHYLENE-PHOSPHONIC ACID

Common Name

English

SAMARATE(5-)-153SM, ((((1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAYL-.KAPPA.N1,.KAPPA.N4,.KAPPA.N7,.KAPPA.N10)TETRAKIS(METHYLENE))TETRAKIS(PHOSPHONATO-.KAPPA.O))(8-))-, PENTAHYDROGEN

Systematic Name

English

SAMARIUM-153 DOTMP

Common Name

English

153SM-DOTMP

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

773120