OLEZARSEN

Approval Year

Substance Class	Nucleic Acid
Nucleic Acid Type	OLIGONUCLEOTIDE
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	S3RS2SA30L
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AKCEA-APOCIII-LRX

Preferred Name

English

OLEZARSEN

Official Name

English

ISIS-678354

Code

English

Olezarsen [WHO-DD]

Common Name

English

olezarsen [INN]

Common Name

English

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Code System

Code

Type

Description

SMS_ID

300000039030

PRIMARY

USAN

HI-29

PRIMARY

FDA UNII

S3RS2SA30L

PRIMARY

NCI_THESAURUS

C180652

PRIMARY

CAS

2097587-83-0

PRIMARY

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Subunit 0

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Sugar	Site Range	Site Count
Deoxyribose (DNA)	1_6-1_15	10 / 20
2'-O-Methoxyethyl ribose	1_1-1_5;1_16-1_20	10 / 20

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Linkage	Site Range	Site Count
Phosporothioate	1_2-1_20	19 / 19

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Related Record

Type

Details


					S3RS2SA30L

OLEZARSEN

ACTIVE MOIETY

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Structural Modifications

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Modification Type	Location Site	Location Type	Residue Modified	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS		UNSPECIFIED SUBSTANCE	6174f862 (not in database)
NUCLEOSIDE BASE SUBSTITUTION	[1_4] [1_5] [1_16] [1_17] [1_18] [1_20]	RESIDUE_SPECIFIC	URACIL	THYMINE	QR26YLT7LT
NUCLEOSIDE BASE SUBSTITUTION	[1_3] [1_6] [1_11] [1_12] [1_15]	RESIDUE_SPECIFIC	CYTOSINE	5-METHYLCYTOSINE	6R795CQT4H

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