U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Nucleic Acid
Created
by admin
on Sat Dec 16 18:34:26 GMT 2023
Edited
by admin
on Sat Dec 16 18:34:26 GMT 2023
Nucleic Acid Type OLIGONUCLEOTIDE
Nucleic Acid Subtype
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
S3RS2SA30L
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
OLEZARSEN
INN   USAN  
Official Name English
ISIS-678354
Code English
olezarsen [INN]
Common Name English
OLEZARSEN [USAN]
Common Name English
IONIS-APOCIII-LRX
Code English
ALL-P-AMBO-5'-O-(((6-(5-((TRIS(3-(6-(2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYLOXY)HEXYLAMINO)-3-OXOPROPOXYMETHYL))METHYL)AMINO-5-OXOPENTANAMIDO)HEXYL))PHOSPHO)-2'-O-(2-METHOXYETHYL)-P-THIOADENYLYL-(3'-O->5'-O)-2'-O-(2-METHOXYETHYL)-P-THIOGUANYLYL-(3'
Systematic Name English
AKCEA-APOCIII-LRX
Code English
DNA, D(P-THIO)((2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))M5RU-M5C-T-T-G-T-M5C-M5C-A-G-M5C-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETH
Common Name English
ISIS-APOCIII-LRX
Code English
Code System Code Type Description
USAN
HI-29
Created by admin on Sat Dec 16 18:34:26 GMT 2023 , Edited by admin on Sat Dec 16 18:34:26 GMT 2023
PRIMARY
FDA UNII
S3RS2SA30L
Created by admin on Sat Dec 16 18:34:26 GMT 2023 , Edited by admin on Sat Dec 16 18:34:26 GMT 2023
PRIMARY
NCI_THESAURUS
C180652
Created by admin on Sat Dec 16 18:34:26 GMT 2023 , Edited by admin on Sat Dec 16 18:34:26 GMT 2023
PRIMARY
CAS
2097587-83-0
Created by admin on Sat Dec 16 18:34:26 GMT 2023 , Edited by admin on Sat Dec 16 18:34:26 GMT 2023
PRIMARY
INN
11801
Created by admin on Sat Dec 16 18:34:26 GMT 2023 , Edited by admin on Sat Dec 16 18:34:26 GMT 2023
PRIMARY
Sugar Site Range Site Count
Deoxyribose (DNA) 1_6-1_15 10 / 20
2'-O-Methoxyethyl ribose 1_1-1_5;1_16-1_20 10 / 20
Linkage Site Range Site Count
Phosporothioate 1_2-1_20 19 / 19
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
NUCLEOTIDE SUBSTITUTION [1_1] 5'-TERMINUS UNSPECIFIED SUBSTANCE
6174f862
(not in database)
NUCLEOSIDE BASE SUBSTITUTION [1_4] [1_5] [1_16] [1_17] [1_18] [1_20] RESIDUE_SPECIFIC URACIL THYMINE QR26YLT7LT
NUCLEOSIDE BASE SUBSTITUTION [1_3] [1_6] [1_11] [1_12] [1_15] RESIDUE_SPECIFIC CYTOSINE 5-METHYLCYTOSINE 6R795CQT4H