SERPLULIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 23:41:26 GMT 2025` Edited by `admin` on `Tue Apr 01 23:41:26 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	S3GQZ2K36V
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SERPLULIMAB

Official Name

English

HLX-10

Preferred Name

English

SERPLULIMAB [USAN]

Common Name

English

serplulimab [INN]

Common Name

English

IMMUNOGLOBULIN G4 (228-PROLINE), ANTI-(HUMAN PROGRAMMED CELL DEATH PROTEIN 1) (HUMAN-MUS MUSCULUS MONOCLONAL HLX10 .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL HLX10 .KAPPA.-CHAIN, DIMER

Common Name

English

Serplulimab [WHO-DD]

Common Name

English

HLX10

Code

English

Classification Tree Code System Code

FDA ORPHAN DRUG

869822

Created by admin on Tue Apr 01 23:41:26 GMT 2025 , Edited by admin on Tue Apr 01 23:41:26 GMT 2025

FDA ORPHAN DRUG

829321

Created by admin on Tue Apr 01 23:41:26 GMT 2025 , Edited by admin on Tue Apr 01 23:41:26 GMT 2025

Code System Code Type Description

CAS

2231029-82-4

Created by admin on Tue Apr 01 23:41:26 GMT 2025 , Edited by admin on Tue Apr 01 23:41:26 GMT 2025

PRIMARY

USAN

NO-43

Created by admin on Tue Apr 01 23:41:26 GMT 2025 , Edited by admin on Tue Apr 01 23:41:26 GMT 2025

PRIMARY

FDA UNII

S3GQZ2K36V

Created by admin on Tue Apr 01 23:41:26 GMT 2025 , Edited by admin on Tue Apr 01 23:41:26 GMT 2025

PRIMARY

SMS_ID

300000013220

Created by admin on Tue Apr 01 23:41:26 GMT 2025 , Edited by admin on Tue Apr 01 23:41:26 GMT 2025

PRIMARY

NCI_THESAURUS

C156738

Created by admin on Tue Apr 01 23:41:26 GMT 2025 , Edited by admin on Tue Apr 01 23:41:26 GMT 2025

PRIMARY

INN

11176

Created by admin on Tue Apr 01 23:41:26 GMT 2025 , Edited by admin on Tue Apr 01 23:41:26 GMT 2025

PRIMARY

From	To
1_225	2_225
1_222	2_222
2_130	4_214
1_130	3_214
4_134	4_194
4_23	4_88
3_134	3_194
3_23	3_88
2_363	2_421
2_257	2_317
2_143	2_199
2_22	2_96
1_363	1_421
1_257	1_317
1_143	1_199
1_22	1_96

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_293
N	2_293

Related Record Type Details


					S3GQZ2K36V

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_443] [2_443]	C-TERMINUS			LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL