Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C31H38O17 |
| Molecular Weight | 682.6232 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 9 / 9 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC(\C=C\C(=O)O[C@H]2[C@H](O)[C@@H](CO)O[C@@]2(CO)O[C@H]3O[C@H](COC(=O)C4=CC=C(O)C=C4)[C@@H](O)[C@H](O)[C@H]3O)=CC(OC)=C1OC
InChI
InChIKey=BBUQNXDJRVCZTI-FNUXIAMKSA-N
InChI=1S/C31H38O17/c1-41-18-10-15(11-19(42-2)27(18)43-3)4-9-22(35)46-28-24(37)20(12-32)47-31(28,14-33)48-30-26(39)25(38)23(36)21(45-30)13-44-29(40)16-5-7-17(34)8-6-16/h4-11,20-21,23-26,28,30,32-34,36-39H,12-14H2,1-3H3/b9-4+/t20-,21-,23-,24-,25+,26-,28+,30-,31+/m1/s1
| Molecular Formula | C31H38O17 |
| Molecular Weight | 682.6232 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 9 / 9 |
| E/Z Centers | 1 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/24076326
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/24076326
Tenuifoliside a (TFSA) is a bioactive oligosaccharide ester component of Polygala tenuifolia Wild, a traditional Chinese medicine that was used to manage mental disorders effectively. It was found, that TFSA exhibited cytoprotective effects on neuronal cells. Further preclinical and clinical trials evaluating their safety, bio efficacy, and bioavailability are suggested to prove the valuable role of natural drugs in the management of depressive disorders. The strong anti-inflammatory effects of tenuifoliside A were mediated by the inhibition of the NF-κB and MAPK pathways, thus tenuifoliside A can be developed as therapeutic for inflammatory diseases.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Plant-derived natural medicines for the management of depression: an overview of mechanisms of action. | 2015 |
|
| Effect of Tenuifoliside A isolated from Polygala tenuifolia on the ERK and PI3K pathways in C6 glioma cells. | 2014-09-15 |
|
| The inhibition of JNK MAPK and NF-κB signaling by tenuifoliside A isolated from Polygala tenuifolia in lipopolysaccharide-induced macrophages is associated with its anti-inflammatory effect. | 2013-12-05 |
Patents
Sample Use Guides
In Vitro Use Guide
Curator's Comment: C6 cells was exposed to Tenuifoliside A (TFSA) (or combined with ERK, PI3K and TrkB inhibitors) to examine the effects of TFSA on the cell viability and the expression and phosphorylation of key proteins in the ERK and PI3K signaling pathway. TFSA increased levels of phospho-ERK and phospho-Akt, enhanced release of BDNF, which were blocked by ERK and PI3K inhibitors, respectively (U0126 and LY294002). Moreover, the TFSA caused the enhanced phosphorylation of cyclic AMP response element binding protein (CREB) at Ser133 site, the effect was revoked by U0126, LY294002 and K252a.
Unknown
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 20:57:49 GMT 2025
by
admin
on
Mon Mar 31 20:57:49 GMT 2025
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| Record UNII |
S36S8L9Y70
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| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID201104704
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46933844
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