U-73343

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C29H42N2O3
Molecular Weight	466.6554
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC2=C(C=C1)[C@H]3CC[C@]4(C)[C@H](CC[C@H]4[C@@H]3CC2)NCCCCCCN5C(=O)CCC5=O

InChI

InChIKey=CJHWFIUASFBCKN-ZRJUGLEFSA-N

InChI=1S/C29H42N2O3/c1-29-16-15-23-22-10-8-21(34-2)19-20(22)7-9-24(23)25(29)11-12-26(29)30-17-5-3-4-6-18-31-27(32)13-14-28(31)33/h8,10,19,23-26,30H,3-7,9,11-18H2,1-2H3/t23-,24-,25+,26+,29+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C29H42N2O3
Molecular Weight	466.6554
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
GO:0004630 \| phospholipase D activity 1 Target ID: GO:0004630 \| phospholipase D activity Sources: https://www.ncbi.nlm.nih.gov/pubmed/9652379	Inhibitor 8504
gastric acid secretion 6 Target ID: GO:0001696 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9316850	Inhibitor 8504
platelet aggregation 80 Target ID: GO:0070527 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9214686	Inhibitor 8504

PubMed

Title	Date	PubMed
Inhibitory effects of U73122 and U73343 on Ca2+ influx and pore formation induced by the activation of P2X7 nucleotide receptors in mouse microglial cell line.	2005-11-15	16122875
U73122 and U73343 inhibit receptor-mediated phospholipase D activation downstream of phospholipase C in CHO cells.	1998-04-10	9652379
The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell.	1997-09	9316850
Human platelet activation is inhibited upstream of the activation of phospholipase A2 by U73343.	1997-05-09	9214686

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:26:38 GMT 2025` Edited by `admin` on `Mon Mar 31 22:26:38 GMT 2025`
Record UNII	S2C4J8704C
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1-(6-((17BETA-3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)-AMINO)HEXYL-2,5-PYRROLIDINE-DIONE

Preferred Name

English

U-73343

Common Name

English

1-(6-(((17.BETA.)-3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL)-2,5-PYRROLIDINEDIONE

Systematic Name

English

2,5-PYRROLIDINEDIONE, 1-(6-(((17.BETA.)-3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL)-

Systematic Name

English

Code System Code Type Description

FDA UNII

S2C4J8704C

Created by admin on Mon Mar 31 22:26:38 GMT 2025 , Edited by admin on Mon Mar 31 22:26:38 GMT 2025

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PUBCHEM

114825

Created by admin on Mon Mar 31 22:26:38 GMT 2025 , Edited by admin on Mon Mar 31 22:26:38 GMT 2025

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CAS

142878-12-4

Created by admin on Mon Mar 31 22:26:38 GMT 2025 , Edited by admin on Mon Mar 31 22:26:38 GMT 2025

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EPA CompTox

DTXSID2036740

Created by admin on Mon Mar 31 22:26:38 GMT 2025 , Edited by admin on Mon Mar 31 22:26:38 GMT 2025

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