Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C20H26N4O5S.ClH |
| Molecular Weight | 470.97 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CN(C)CC1=CC=C(CSCCNC(NCC2=CC=C3OCOC3=C2)=C[N+]([O-])=O)O1
InChI
InChIKey=YGFCDHGCXUXBRI-BGDWDFROSA-N
InChI=1S/C20H26N4O5S.ClH/c1-23(2)11-16-4-5-17(29-16)13-30-8-7-21-20(12-24(25)26)22-10-15-3-6-18-19(9-15)28-14-27-18;/h3-6,9,12,21-22H,7-8,10-11,13-14H2,1-2H3;1H/b20-12+;
| Molecular Formula | C20H26N4O5S |
| Molecular Weight | 434.509 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Niperotidine is an H2 antagonist structurally related to ranitidine. H2 antagonists inhibit gastric acid secretion by selectively blocking histamine receptor type 2. Niperotidine was proposed for the treatment of peptic ulcer. Bedtime dose of niperotidine inhibits nocturnal gastric acid secretion in healthy subjects. The duration of niperotidine action was 5 to 7 hours. Twenty-five cases of acute hepatitis (including one death from fulminant hepatitis) associated with niperotidine use were reported in Italy between March and August 1995 and drug was withdrawn from the market. The methylenedioxy group of niperotidine is known to undergo metabolism to catechol and quinone metabolites.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 06:16:55 UTC 2023
by
admin
on
Sat Dec 16 06:16:55 UTC 2023
|
| Record UNII |
S1N0RH6385
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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SUB03436MIG
Created by
admin on Sat Dec 16 06:16:55 UTC 2023 , Edited by admin on Sat Dec 16 06:16:55 UTC 2023
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100000085719
Created by
admin on Sat Dec 16 06:16:55 UTC 2023 , Edited by admin on Sat Dec 16 06:16:55 UTC 2023
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S1N0RH6385
Created by
admin on Sat Dec 16 06:16:55 UTC 2023 , Edited by admin on Sat Dec 16 06:16:55 UTC 2023
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76965442
Created by
admin on Sat Dec 16 06:16:55 UTC 2023 , Edited by admin on Sat Dec 16 06:16:55 UTC 2023
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PRIMARY |
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |