Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C13H14N2.2ClH |
| Molecular Weight | 271.186 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.NC1=CC=C(CC2=CC=C(N)C=C2)C=C1
InChI
InChIKey=MXNNTNFLRICRPT-UHFFFAOYSA-N
InChI=1S/C13H14N2.2ClH/c14-12-5-1-10(2-6-12)9-11-3-7-13(15)8-4-11;;/h1-8H,9,14-15H2;2*1H
| Molecular Formula | C13H14N2 |
| Molecular Weight | 198.2637 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis. | 2016-01 |
|
| 4,4'-Methylenedianiline Alters Serotonergic Transport in a Novel, Sex-Specific Model of Pulmonary Arterial Hypertension in Rats. | 2015-09 |
|
| Genomic models of short-term exposure accurately predict long-term chemical carcinogenicity and identify putative mechanisms of action. | 2014 |
|
| Expression of hepatocytic- and biliary-specific transcription factors in regenerating bile ducts during hepatocyte-to-biliary epithelial cell transdifferentiation. | 2010-12-02 |
|
| Determination of aromatic amines in aqueous extracts of polyurethane foam using hydrophilic interaction liquid chromatography and mass spectrometry. | 2010-09-23 |
|
| Primary aromatic amines (PAAs) in black nylon and other food-contact materials, 2004-2009. | 2010-09 |
|
| Ortho-rhom-bic modification of bis-[4-(3-pyridyl-methyl-idene-amino)-phen-yl]methane. | 2010-08-18 |
|
| A structural and spectroscopic investigation of the hydrochlorination of 4,4'-methylenedianiline. | 2010-04-21 |
|
| Curing and dynamic mechanical thermal properties of epoxy/clay nanocomposites. | 2010-04 |
|
| Validation of a liquid chromatography-mass spectrometry method for determining the migration of primary aromatic amines from cooking utensils and its application to actual samples. | 2010-01 |
|
| [Migration of monomers and primary aromatic amines from nylon products]. | 2010 |
|
| The role of bridging ligands in determining DNA-binding ability and cross-linking patterns of dinuclear platinum(II) antitumour complexes. | 2009-12-28 |
|
| New isocyanate-specific albumin adducts of 4,4'-methylenediphenyl diisocyanate (MDI) in rats. | 2009-12 |
|
| Determination of aromatic amines in food products and composite food packaging bags by capillary electrophoresis coupled with transient isotachophoretic stacking. | 2009-10-23 |
|
| Identification of urinary biomarkers useful for distinguishing a difference in mechanism of toxicity in rat model of cholestasis. | 2009-09 |
|
| N,N'-(Methyl-enedi-p-phenyl-ene)dibenzamide. | 2009-08-12 |
|
| [Analysis of primary aromatic amines in paper products]. | 2009-08 |
|
| Three cases of allergic contact dermatitis to 4,4'-diaminodiphenylmethane. | 2009-06 |
|
| Synthesis and characterization of new optically active poly(azo-ester-imide)s via interfacial polycondensation. | 2009-03 |
|
| Characterization of biliary conjugates of 4,4'-methylenedianiline in male versus female rats. | 2008-10-15 |
|
| Study of the infrared spectral features of an epoxy curing mechanism. | 2008-10 |
|
| Reactivity of in vitro activated human T lymphocytes to p-phenylenediamine and related substances. | 2008-10 |
|
| 4,4'-Methyl-enedianilinium bis-(3-carb-oxy-4-hydroxy-benzene-sulfonate) monohydrate. | 2008-09-17 |
|
| Bis(1,2,3,4-tetra-hydro-quinolin-6-yl)methane. | 2008-08-13 |
|
| Contact sensitization to 4,4'-diaminodiphenylmethane and to isocyanates among general dermatology patients. | 2008-08 |
|
| Time- and dose-based gene expression profiles produced by a bile-duct-damaging chemical, 4,4'-methylene dianiline, in mouse liver in an acute phase. | 2008-07 |
|
| Organic-solvent extraction of model biomaterials for use in the in vitro chromosome aberration test. | 2008-07 |
|
| Percutaneous absorption of aromatic amines - a contribution for human health risk assessment. | 2008-06 |
|
| Liquid chromatography-electrospray tandem mass spectrometry investigations of fragmentation pathways of biliary 4,4'-methylenedianiline conjugates produced in rats. | 2008-05 |
|
| Validation of putative genomic biomarkers of nephrotoxicity in rats. | 2008-04-18 |
|
| Bis(4,4'-methyl-enedianilinium) naphthalene-1,5-disulfonate dihydrate. | 2008-03-20 |
|
| Bile duct destruction by 4,4'-diaminodiphenylmethane does not block the small hepatocyte-like progenitor cell response in retrorsine-exposed rats. | 2007-11 |
|
| How to optimize patch testing with diphenylmethane diisocyanate. | 2007-09 |
|
| Determination of isocyanate biomarkers in construction site workers. | 2007-08-19 |
|
| 4,4'-Methylenedianiline and its dihydrochloride salt. | 2004 |
|
| Study on cross-reactivity to the para group. | 1990 |
|
| [The value of positive epicutaneous test reactions to 4,4'-diaminodiphenylmethane]. | 1989-01-01 |
|
| Retinopathy from inhaling 4,4'-methylenedianiline aerosols. | 1987-11 |
|
| Sensitization to methylenedianiline and para-structures. | 1987-05 |
|
| Inhibition of neoplastic development in rat liver, kidney, oesophagus and forestomach by 4,4'-diaminodiphenylmethane administration. | 1987-05 |
|
| [Change in the allergen spectrum in contact eczema 1975-1984]. | 1987-01-01 |
|
| Carcinogenesis studies of 4,4'-methylenedianiline dihydrochloride given in drinking water to F344/N rats and B6C3F1 mice. | 1986 |
|
| Yellow staining caused by 4,4'-methylenedianiline exposure. Occurrence among molded plastics workers. | 1985-08 |
|
| Methylene dianilene: a new toxic cause of visual failure with hepatitis. | 1985-01 |
|
| Occupational hepatitis caused by methylenedianiline. | 1984-10-13 |
|
| Neoplastic response of F344 rats and B6C3F1 mice to the polymer and dyestuff intermediates 4,4'-methylenebis(N,N-dimethyl)-benzenamine, 4,4'-oxydianiline, and 4,4'-methylenedianiline. | 1984-06 |
|
| 4,4'-Diaminodiphenylmethane: promoting effect on the development of thyroid tumors in rats treated with N-bis(2-hydroxypropyl)nitrosamine. | 1984-02 |
|
| [Infrahepatic bile duct proliferation in the gestating rat treated with 4,4'-diaminodiphenylmethane (4,4DDPM)]. | 1983-12 |
|
| Occupational photosensitivity to diaminodiphenylmethane. | 1983-11 |
|
| Effect of various factors on the induction of liver tumors in animals by quinoline. | 1977-12 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:26:47 GMT 2025
by
admin
on
Mon Mar 31 19:26:47 GMT 2025
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| Record UNII |
S0V6PBT14R
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| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID9020871
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26108
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13552-44-8
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S0V6PBT14R
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236-934-2
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PARENT -> SALT/SOLVATE |
