| Stereochemistry | MIXED |
| Molecular Formula | C24H25NO3 |
| Molecular Weight | 375.4602 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 0 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)=CC1C(C(=O)OC(C#N)C2=CC=CC(OC3=CC=CC=C3)=C2)C1(C)C
InChI
InChIKey=FJDPATXIBIBRIM-UHFFFAOYSA-N
InChI=1S/C24H25NO3/c1-16(2)13-20-22(24(20,3)4)23(26)28-21(15-25)17-9-8-12-19(14-17)27-18-10-6-5-7-11-18/h5-14,20-22H,1-4H3
| Molecular Formula | C24H25NO3 |
| Molecular Weight | 375.4602 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | MIXED |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Cyphenothrin is one of the type II pyrethroid insecticide, in combination with fipronil it used to provide dogs with protection to common topical parasites in dogs. Cyphenothrin primarily affects sodium channels in excitable membranes causing a prolongation of the sodium current during excitation. The prolonged sodium current results in the development of a depolarizing after potential following the action and is responsible for the induction of repetitive activity, which is the most characteristic effect of pyrethroid poisoning in the nervous system. At low concentrations, insects and other arthropods suffer from hyperactivity. At high concentrations, they are paralyzed and die.
CNS Activity
Originator
Approval Year
Sample Use Guides
for dogs: The dose of Parastar Plus® (Fipronil mixed with a second ingredient cyphenothrin) and Fiproguard Max® (is the same product as Parastar Plus but by a different manufacturer) is based on the weight of the dog and pipettes are available in 0.67 mL (for dogs from 4 to 22 pounds), 1.34 mL (for dogs 23 to 44 pounds), 2.68 mL (for dogs 45 to 88 pounds) and 4.02 mL (for dogs 89 to 132 pounds). One pipette is applied topically every 30 days. The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects.
Route of Administration:
Oral
Experiments were performed using the mouse neuroblastoma cell line NIE-115. Three main effects of the cyphenothrin (25 uM) was found: (1) the peak amplitude of the sodium current increased; (2) the declining phase of the sodium current during depolarization was greatly slowed down resuilting in a marked residual current towards the end of tlhe 15 ms pulse; and (3) after repolarization of the membrane to the holding potential a large, slowly decaying sodium tail current remained.