U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C8H18N2O4S
Molecular Weight 238.305
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID

SMILES

OCCN1CCN(CCS(O)(=O)=O)CC1

InChI

InChIKey=JKMHFZQWWAIEOD-UHFFFAOYSA-N
InChI=1S/C8H18N2O4S/c11-7-5-9-1-3-10(4-2-9)6-8-15(12,13)14/h11H,1-8H2,(H,12,13,14)

HIDE SMILES / InChI

Molecular Formula C8H18N2O4S
Molecular Weight 238.305
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID (wider known as HEPES), a zwitterionic buffering agent, is one of the best all-purpose buffers available for use in biological research. HEPES is most effective as a buffer at pH 6.0 to 8.5. It was shown that HEPES could be taken into account as simple and efficient reagent for promoting protein transfection and intracellular targeting and had the potential for myriad clinical applications.

Approval Year

PubMed

PubMed

TitleDatePubMed
Utilization of HEPES for Enhancing Protein Transfection into Mammalian Cells.
2019 Jun 14
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:28:15 GMT 2023
Edited
by admin
on Fri Dec 15 15:28:15 GMT 2023
Record UNII
RWW266YE9I
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID
II   INCI  
INCI  
Official Name English
4-(2-HYDROXYETHYL)-1-PIPERAZINEETHANE SULFONIC ACID
Systematic Name English
4-(2-HYDROXYETHYL)PIPERAZIN-1-YLETHANESULPHONIC ACID
Systematic Name English
2-(4-(2-HYDROXYETHYL)PIPERAZIN-1-YL)ETHANESULFONIC ACID
Systematic Name English
HEPES
MI  
Common Name English
HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID [INCI]
Common Name English
HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID [II]
Common Name English
HEPES [MI]
Common Name English
NSC-166663
Code English
1-PIPERAZINEETHANESULFONIC ACID, 4-(2-HYDROXYETHYL)-
Common Name English
N-2-HYDROXYETHYLPIPERAZINE N'-2'-ETHANESULPHONIC ACID
Common Name English
Code System Code Type Description
ECHA (EC/EINECS)
230-907-9
Created by admin on Fri Dec 15 15:28:15 GMT 2023 , Edited by admin on Fri Dec 15 15:28:15 GMT 2023
PRIMARY
EPA CompTox
DTXSID5040382
Created by admin on Fri Dec 15 15:28:15 GMT 2023 , Edited by admin on Fri Dec 15 15:28:15 GMT 2023
PRIMARY
NSC
166663
Created by admin on Fri Dec 15 15:28:15 GMT 2023 , Edited by admin on Fri Dec 15 15:28:15 GMT 2023
PRIMARY
CHEBI
42334
Created by admin on Fri Dec 15 15:28:15 GMT 2023 , Edited by admin on Fri Dec 15 15:28:15 GMT 2023
PRIMARY
PUBCHEM
23830
Created by admin on Fri Dec 15 15:28:15 GMT 2023 , Edited by admin on Fri Dec 15 15:28:15 GMT 2023
PRIMARY
RXCUI
1312611
Created by admin on Fri Dec 15 15:28:15 GMT 2023 , Edited by admin on Fri Dec 15 15:28:15 GMT 2023
PRIMARY RxNorm
WIKIPEDIA
HEPES
Created by admin on Fri Dec 15 15:28:15 GMT 2023 , Edited by admin on Fri Dec 15 15:28:15 GMT 2023
PRIMARY
SMS_ID
100000129773
Created by admin on Fri Dec 15 15:28:15 GMT 2023 , Edited by admin on Fri Dec 15 15:28:15 GMT 2023
PRIMARY
FDA UNII
RWW266YE9I
Created by admin on Fri Dec 15 15:28:15 GMT 2023 , Edited by admin on Fri Dec 15 15:28:15 GMT 2023
PRIMARY
MERCK INDEX
m5959
Created by admin on Fri Dec 15 15:28:15 GMT 2023 , Edited by admin on Fri Dec 15 15:28:15 GMT 2023
PRIMARY Merck Index
NCI_THESAURUS
C80933
Created by admin on Fri Dec 15 15:28:15 GMT 2023 , Edited by admin on Fri Dec 15 15:28:15 GMT 2023
PRIMARY
CAS
7365-45-9
Created by admin on Fri Dec 15 15:28:15 GMT 2023 , Edited by admin on Fri Dec 15 15:28:15 GMT 2023
PRIMARY
DAILYMED
RWW266YE9I
Created by admin on Fri Dec 15 15:28:15 GMT 2023 , Edited by admin on Fri Dec 15 15:28:15 GMT 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 15:28:15 GMT 2023 , Edited by admin on Fri Dec 15 15:28:15 GMT 2023
CONCEPT Industrial Aid
EVMPD
SUB40482
Created by admin on Fri Dec 15 15:28:15 GMT 2023 , Edited by admin on Fri Dec 15 15:28:15 GMT 2023
PRIMARY