Details
Stereochemistry | ACHIRAL |
Molecular Formula | C22H29N3S2.2C4H4O4 |
Molecular Weight | 631.76 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 2 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CCSC1=CC2=C(SC3=C(C=CC=C3)N2CCCN4CCN(C)CC4)C=C1
InChI
InChIKey=RVBRTNPNFYFDMZ-SPIKMXEPSA-N
InChI=1S/C22H29N3S2.2C4H4O4/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24;2*5-3(6)1-2-4(7)8/h4-5,7-10,17H,3,6,11-16H2,1-2H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
Molecular Formula | C22H29N3S2 |
Molecular Weight | 399.616 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C4H4O4 |
Molecular Weight | 116.0722 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 1 |
Optical Activity | NONE |
Thiethylperazine is a antiemetic, which was used for the treatment of nausea and vomiting in patients undergoing radiotherapy, chemotherapy or as a postoperative care. Thiethylperazine exerts its therapeutic effect by blocking dopamine receptors in brain. The drug is capable of potentiating CNS depressants as well as atropine.
CNS Activity
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Secondary | TORECAN Approved UseTo relieve nausea and vomitin associated with postoperative recovery, radiation therapy, chemotherapy, acute situations. Launch Date-2.66889593E11 |
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Secondary | TORECAN Approved UseTo relieve nausea and vomitin associated with postoperative recovery, radiation therapy, chemotherapy, acute situations. Launch Date-2.66889593E11 |
Doses
Dose | Population | Adverse events |
---|---|---|
100 mg 1 times / day single, oral Overdose Dose: 100 mg, 1 times / day Route: oral Route: single Dose: 100 mg, 1 times / day Sources: |
unhealthy, 12 n = 1 Health Status: unhealthy Condition: migraine Age Group: 12 Sex: F Population Size: 1 Sources: |
Other AEs: Dystonia, Hyperreflexia... |
150 mg 6 times / day multiple, oral (max) Highest studied dose Dose: 150 mg, 6 times / day Route: oral Route: multiple Dose: 150 mg, 6 times / day Sources: |
unhealthy, 22-53 n = 10 Health Status: unhealthy Condition: schizophrenia Age Group: 22-53 Sex: M+F Population Size: 10 Sources: |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Dystonia | 100 mg 1 times / day single, oral Overdose Dose: 100 mg, 1 times / day Route: oral Route: single Dose: 100 mg, 1 times / day Sources: |
unhealthy, 12 n = 1 Health Status: unhealthy Condition: migraine Age Group: 12 Sex: F Population Size: 1 Sources: |
|
Hyperreflexia | 100 mg 1 times / day single, oral Overdose Dose: 100 mg, 1 times / day Route: oral Route: single Dose: 100 mg, 1 times / day Sources: |
unhealthy, 12 n = 1 Health Status: unhealthy Condition: migraine Age Group: 12 Sex: F Population Size: 1 Sources: |
PubMed
Title | Date | PubMed |
---|---|---|
[Extrapyramidal syndrome as a side-effect of treatment with thiethylperazine (torecan) and metoclopramide (Reglan) a review of ten cases (author's transl)]. | 1977 Mar |
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Thiethylperazine (Torecan)-associated dystonic reactions in children. | 1979 Dec |
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Dystonic reactions following thiethylperazine in children. | 1982 Oct |
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Identification of phenothiazine antihistamines and their metabolites in urine. | 1988 |
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Chronic hemidystonia following acute dystonic reaction to thiethylperazine. | 1991 Jun |
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[Dyskinesis after a single dose of thiethylperazine during the first trimester of pregnancy]. | 1994 Feb 21-28 |
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Preliminary results. UFT/methotrexate/leucovorin for breast Ca patients in progression after HDCT/PBPC support. | 1997 Sep |
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Thiethylperazine-induced parkinsonism: in vivo demonstration of dopamine D2 receptors blockade. | 2004 Oct |
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Evaluation of maternal infusion therapy during pregnancy for fetal development. | 2005 |
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Drug treatment during pregnancy and isolated orofacial clefts in hungary. | 2007 Mar |
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High-degree atrioventricular block in acute ethanol poisoning: a case report. | 2009 Sep 9 |
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Enhancement of vancomycin activity by phenothiazines against vancomycin-resistant Enterococcus faecium in vitro. | 2010 Aug |
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Improving management of patients with advanced cancer. | 2010 Dec 2 |
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Acute ECG ST-segment elevation mimicking myocardial infarction in a patient with pulmonary embolism. | 2010 Nov 24 |
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Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice. | 2011 Oct |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:05:32 UTC 2023
by
admin
on
Fri Dec 15 15:05:32 UTC 2023
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Record UNII |
RUK64CF26E
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C267
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SUB71453
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SUB04808MIG
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m10737
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RUK64CF26E
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C29497
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DBSALT001059
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100000091798
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CHEMBL1378
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130044
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214-648-9
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Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE | |||
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |