| Stereochemistry | ABSOLUTE |
| Molecular Formula | C32H41N5O4 |
| Molecular Weight | 559.699 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCC(=O)C1(CCN(CC1)C(=O)[C@@H](CC2=CC=C(OC)C=C2)NC(=O)[C@@H](N)CC3=CN=CN3C)C4=CC=CC=C4
InChI
InChIKey=GULVVTHHUIIMRL-WUFINQPMSA-N
InChI=1S/C32H41N5O4/c1-4-8-29(38)32(24-9-6-5-7-10-24)15-17-37(18-16-32)31(40)28(19-23-11-13-26(41-3)14-12-23)35-30(39)27(33)20-25-21-34-22-36(25)2/h5-7,9-14,21-22,27-28H,4,8,15-20,33H2,1-3H3,(H,35,39)/t27-,28+/m0/s1
| Molecular Formula | C32H41N5O4 |
| Molecular Weight | 559.699 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
BMS-470539 2 HCL (BMS-470539) is a potent, specific MC1R ligand. The
affinity of this molecule, as determined by [125I]NDP-MSH
competition binding experiments, was in the nanomolar
range (IC50 120 nM). BMS-470539 is a
potent, full agonist of recombinant human MC-1R, stably expressed
in CHO cells, with an EC50 of 16.8 nM and an intrinsic
activity of 88% in a cAMP accumulation assay. BMS-470539 exhibits anti-inflammatory properties following ischemia-reperfusion in the vasculature. BMS-470539 inhibits leukocyte trafficking. In mice, BMS-470539 inhibits lipopolysaccharide (LPS)-induced systemic tumour necrosis factor (TNF) release and LPS-induced leucocyte migration into the lung.
Originator
Approval Year
PubMed
Patents
Sample Use Guides
Mice: Male BALB/c mice were dosed with BMS-
470539, as an i.v. bolus or s.c. injection at 33 umol/kg (18.47 mg/kg) in a
vehicle consisting of a 50% poly(ethylene glycol)/50% water mixture (100
ul/mouse).
Route of Administration:
Other
