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Details

Stereochemistry ACHIRAL
Molecular Formula Co.2O4S.2H4N
Molecular Weight 287.135
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMMONIUM COBALTOUS SULFATE

SMILES

[NH4+].[NH4+].[Co++].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O

InChI

InChIKey=NUHXWPRATKOXDB-UHFFFAOYSA-L
InChI=1S/Co.2H3N.2H2O4S/c;;;2*1-5(2,3)4/h;2*1H3;2*(H2,1,2,3,4)/q+2;;;;/p-2

HIDE SMILES / InChI
Molecular Formula H4N
Molecular Weight 18.0385
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula O4S
Molecular Weight 96.063
Charge -2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula Co
Molecular Weight 58.9332
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/104729ISBN 9780873715980, Foden C.R., Weddell J.L., 'Hazardous Materials: Emergency Action Data' (1991), Retrieved from https://books.google.com/books?id=4IPE8Pjhm8UC&pgISBN: 978-94-010-7024-9, Matar M.S., Mirbach M.J.,Tayim H.A. 'Catalysis in Petrochemical Processes' (1988), p.136, Retrieved from https://books.google.com/books?id=MkD2JnDkZYYC&dqhttp://aygrt.isrj.org/colorArticles/4972.pdfhttp://onlinelibrary.wiley.com/doi/10.1002/3527600418.mb744048e0023/pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27527840https://fscimage.fishersci.com/msds/05330.htmhttp://laboratorychemicals.in/uploads/msds/10026-17-2-49128.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/2253206https://monographs.iarc.fr/ENG/Monographs/vol52/mono52-16.pdfhttp://datasheets.scbt.com/sc-227251.pdf
Curator's Comment: description was created based on several sources, including: DOI:10.1080/00958970802416020 | DOI:10.1080/00958972.2010.521553 | https://www.ncbi.nlm.nih.gov/pubmed/7201957 | https://www.ncbi.nlm.nih.gov/pubmed/18475879

Cobaltous iodide is a catalyst used in organic synthesis.

Originator

Brandt, G.
20
Curator's Comment: Cobalt was discovered by Georg Brandt, a Swedish chemist, in 1739.

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Hypoxia-inducible factor 1-alpha inhibitor
22
Target ID: Q9NWT6
Gene ID: 55662.0
Gene Symbol: HIF1AN
Target Organism: Homo sapiens (Human)
Inhibitor
8297
 1.0 µM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Withdrawn
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Erythropoietic effect of cobalt in patients with or without anemia.
1949 May 12
Inhalation toxicity studies of cobalt sulfate in F344/N rats and B6C3F1 mice.
1990 Aug
Determination of trace metal ions in common salt by stripping voltammetry.
1999 Nov-Dec
Cobalt and antimony: genotoxicity and carcinogenicity.
2003 Dec 10
Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway.
2005 Aug
Expression of surface markers on the human monocytic leukaemia cell line, THP-1, as indicators for the sensitizing potential of chemicals.
2009 Apr
In vitro assessment of cobalt oxide particle toxicity: identifying and circumventing interference.
2013 Sep
Purification and characterization of glucose 6-phosphate dehydrogenase enzyme from rainbow trout (Oncorhynchus mykiss) liver and investigation of the effects of some metal ions on enzyme activity.
2015 May
Differential pulmonary effects of CoO and La2O3 metal oxide nanoparticle responses during aerosolized inhalation in mice.
2016 Aug 15
Patents

Patents

US20150010463
20
US3459677 A
20
US4326084
20
US5718844
20
US6740618 B2
20
WO2014127808A1
20

Sample Use Guides

In Vivo Use Guide
For treatment of anemia, oral cobal chloride was administered at doses 25 mg and 50 mg daily.
Route of Administration: Oral
In Vitro Use Guide
HIF asparaginyl hydroxylase activity was measured by a method based on the hydroxylation coupled decarboxylation of 2-oxoglutarate with the synthetic HIF-1α peptides in the presence of varying concentrations of Co (1-5 uM). Ki for HIF asparaginyl hydroxylase was 1uM.
Substance Class Chemical
Created
by admin
on Sat Dec 16 09:17:13 GMT 2023
Edited
by admin
on Sat Dec 16 09:17:13 GMT 2023
Record UNII
RQ334XLD0M
Record Status Validated (UNII)
Record Version
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Name Type Language
AMMONIUM COBALTOUS SULFATE
MI  
Common Name English
SULFURIC ACID, AMMONIUM COBALT(2+) SALT
Common Name English
COBALT(II) AMMONIUM SULFATE
Systematic Name English
AMMONIUM COBALTOUS SULFATE [MI]
Common Name English
AMMONIUM COBALT SULFATE (2:1:2)
Systematic Name English
Code System Code Type Description
MERCK INDEX
m39
Created by admin on Sat Dec 16 09:17:13 GMT 2023 , Edited by admin on Sat Dec 16 09:17:13 GMT 2023
PRIMARY Merck Index
PUBCHEM
26125
Created by admin on Sat Dec 16 09:17:13 GMT 2023 , Edited by admin on Sat Dec 16 09:17:13 GMT 2023
PRIMARY
CAS
13596-46-8
Created by admin on Sat Dec 16 09:17:13 GMT 2023 , Edited by admin on Sat Dec 16 09:17:13 GMT 2023
PRIMARY
ECHA (EC/EINECS)
237-043-1
Created by admin on Sat Dec 16 09:17:13 GMT 2023 , Edited by admin on Sat Dec 16 09:17:13 GMT 2023
PRIMARY
EPA CompTox
DTXSID80890709
Created by admin on Sat Dec 16 09:17:13 GMT 2023 , Edited by admin on Sat Dec 16 09:17:13 GMT 2023
PRIMARY
FDA UNII
RQ334XLD0M
Created by admin on Sat Dec 16 09:17:13 GMT 2023 , Edited by admin on Sat Dec 16 09:17:13 GMT 2023
PRIMARY
CAS
1314094-34-2
Created by admin on Sat Dec 16 09:17:13 GMT 2023 , Edited by admin on Sat Dec 16 09:17:13 GMT 2023
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