ETOXADROL, (±)-

Details

Stereochemistry	RACEMIC
Molecular Formula	C16H23NO2
Molecular Weight	261.3593
Optical Activity	( + / - )
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]1(CO[C@@](CC)(O1)C2=CC=CC=C2)[C@]3([H])CCCCN3

InChI

InChIKey=INOYCBNLWYEPSB-XHSDSOJGSA-N

InChI=1S/C16H23NO2/c1-2-16(13-8-4-3-5-9-13)18-12-15(19-16)14-10-6-7-11-17-14/h3-5,8-9,14-15,17H,2,6-7,10-12H2,1H3/t14-,15+,16-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C16H23NO2
Molecular Weight	261.3593
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/16169732 | https://www.ncbi.nlm.nih.gov/pubmed/5921 | https://www.ncbi.nlm.nih.gov/pubmed/6118431 | https://www.ncbi.nlm.nih.gov/pubmed/4085541

Etoxadrol is an NMDA receptor antagonist. It exerts phencyclidine-like properties. Etoxadrol has anticonvulsant and anesthetic activity. Intravenous etoxadrol was clinically tested as an anesthetic.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Glutamate [NMDA] receptor 125 Target ID: CHEMBL2094124 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16169732	Antagonist 2778		19.8 null [Ki]

PubMed

Title	Date	PubMed
Effects of intravenous anesthetics on continuous avoidance behavior in the rat.	1976 Feb	5976
Clinical investigation of a new intravenous anesthetic--etoxadrol hydrochloride (CL-1848; U-37862A).	1976 May-Jun	5921

Sample Use Guides

In Vivo Use Guide

0.75 mg/kg

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Sat Dec 16 14:49:12 GMT 2023` Edited by `admin` on `Sat Dec 16 14:49:12 GMT 2023`
Record UNII	RO44G6QT80
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ETOXADROL, (±)-

Common Name

English

PIPERIDINE, 2-(2-ETHYL-2-PHENYL-1,3-DIOXOLAN-4-YL)-, (2.ALPHA.,4.BETA.(R*))-(±)-

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID00865419

Created by admin on Sat Dec 16 14:49:12 GMT 2023 , Edited by admin on Sat Dec 16 14:49:12 GMT 2023

PRIMARY

CAS

30163-01-0

Created by admin on Sat Dec 16 14:49:12 GMT 2023 , Edited by admin on Sat Dec 16 14:49:12 GMT 2023

PRIMARY

PUBCHEM

14208380

Created by admin on Sat Dec 16 14:49:12 GMT 2023 , Edited by admin on Sat Dec 16 14:49:12 GMT 2023

PRIMARY

FDA UNII

RO44G6QT80

Created by admin on Sat Dec 16 14:49:12 GMT 2023 , Edited by admin on Sat Dec 16 14:49:12 GMT 2023

PRIMARY

Related Record Type Details


					9A5JD3CML6

ETOXADROL HYDROCHLORIDE, (±)-

SALT/SOLVATE -> PARENT

Amount:

Details

SMILES

InChI

DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/16169732 | https://www.ncbi.nlm.nih.gov/pubmed/5921 | https://www.ncbi.nlm.nih.gov/pubmed/6118431 | https://www.ncbi.nlm.nih.gov/pubmed/4085541

CNS Activity

Approval Year

Targets

PubMed

Sample Use Guides

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/16169732 | https://www.ncbi.nlm.nih.gov/pubmed/5921 | https://www.ncbi.nlm.nih.gov/pubmed/6118431 | https://www.ncbi.nlm.nih.gov/pubmed/4085541