U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 06:54:33 GMT 2023
Edited
by admin
on Sat Dec 16 06:54:33 GMT 2023
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG4
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
RM898LZ4SI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Sirexatamab
INN  
Official Name English
IMMUNOGLOBULIN G4 (224-PROLINE,233-ALANINE,234-ALANINE), ANTI-(HUMAN DICKKOPF-1) (HUMAN-MUS MUSCULUS MONOCLONAL DKN-01 .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL DKN-01 .KAPPA.-CHAIN, DIMER
Common Name English
DKK1-NEUTRALIZING MONOCLONAL ANTIBODY DKN-01
Common Name English
DKN01
Code English
sirexatamab [INN]
Common Name English
LY-2812176
Code English
DKN 01 [WHO-DD]
Common Name English
DKN-01
Code English
ANTI-DKK-1 MONOCLONAL ANTIBODY LY2812176
Common Name English
LY2812176
Code English
Classification Tree Code System Code
FDA ORPHAN DRUG 744020
Created by admin on Sat Dec 16 06:54:33 GMT 2023 , Edited by admin on Sat Dec 16 06:54:33 GMT 2023
NCI_THESAURUS C20401
Created by admin on Sat Dec 16 06:54:33 GMT 2023 , Edited by admin on Sat Dec 16 06:54:33 GMT 2023
NCI_THESAURUS C129822
Created by admin on Sat Dec 16 06:54:33 GMT 2023 , Edited by admin on Sat Dec 16 06:54:33 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C99123
Created by admin on Sat Dec 16 06:54:33 GMT 2023 , Edited by admin on Sat Dec 16 06:54:33 GMT 2023
PRIMARY
INN
11751
Created by admin on Sat Dec 16 06:54:33 GMT 2023 , Edited by admin on Sat Dec 16 06:54:33 GMT 2023
PRIMARY
FDA UNII
RM898LZ4SI
Created by admin on Sat Dec 16 06:54:33 GMT 2023 , Edited by admin on Sat Dec 16 06:54:33 GMT 2023
PRIMARY
CAS
2414962-49-3
Created by admin on Sat Dec 16 06:54:33 GMT 2023 , Edited by admin on Sat Dec 16 06:54:33 GMT 2023
PRIMARY
NCI_THESAURUS
C113331
Created by admin on Sat Dec 16 06:54:33 GMT 2023 , Edited by admin on Sat Dec 16 06:54:33 GMT 2023
ALTERNATIVE
From To
1_22 1_96
2_22 2_96
2_133 4_214
2_146 2_202
2_260 2_320
1_133 3_214
2_366 2_424
3_23 3_88
3_134 3_194
4_23 4_88
4_134 4_194
1_146 1_202
1_225 2_225
1_228 2_228
1_260 1_320
1_366 1_424
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_296
N 2_296
Related Record Type Details
TARGET -> INHIBITOR
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL