5-Methyl-2-(1-methylethyl)-4-nitrosophenol

CC(C)C1=C(O)C=C(C)C(=C1)N=O

InChIKey=YQVCMSSJMLGWAM-UHFFFAOYSA-N

InChI=1S/C10H13NO2/c1-6(2)8-5-9(11-13)7(3)4-10(8)12/h4-6,12H,1-3H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Potency
Serine/threonine-protein kinase PLK1 15 Target ID: CHEMBL3024 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18482698 \| https://www.ncbi.nlm.nih.gov/pubmed/23135290	Inhibitor 8504	4.8 µM [IC50]
Serine/threonine-protein kinase PLK2 1 Target ID: CHEMBL5938 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18482698	Inhibitor 8504	18.7 µM [IC50]
Serine/threonine-protein kinase PLK3 1 Target ID: CHEMBL4897 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18482698	Inhibitor 8504	53.9 µM [IC50]

PubMed

Title	Date	PubMed
Thymoquinone blocks pSer/pThr recognition by Plk1 Polo-box domain as a phosphate mimic.	2013-02-15	23135290
Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions.	2008-05	18482698

Substance Class	Chemical Created by `admin` on `Tue Apr 01 20:01:59 GMT 2025` Edited by `admin` on `Tue Apr 01 20:01:59 GMT 2025`
Record UNII	RLW2ZRP3KC
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

5-Methyl-2-(1-methylethyl)-4-nitrosophenol

Systematic Name

English

NSC-32670

Preferred Name

English

NSC-5054

Code

English

NSC-406196

Code

English

PHENOL, 5-METHYL-2-(1-METHYLETHYL)-4-NITROSO-

Common Name

English

2-Isopropyl-5-methyl-4-nitrosophenol

Systematic Name

English

Code System Code Type Description

NSC

5054