Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C18H19N3O.ClH |
| Molecular Weight | 329.824 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CN1C2=C(C3=C1C=CC=C3)C(=O)[C@H](CN4C=CN=C4C)CC2
InChI
InChIKey=MKBLHFILKIKSQM-ZOWNYOTGSA-N
InChI=1S/C18H19N3O.ClH/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H/t13-;/m0./s1
| Molecular Formula | C18H19N3O |
| Molecular Weight | 293.363 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| IgE-mediated allergy to granisetron and safe use of ondansetron. | 2001-12 |
|
| Serotonin localization in Phallusia mammillata larvae and effects of 5-HT antagonists during larval development. | 2001-12 |
|
| Analgesic efficacy of tramadol if coadministered with ondansetron. | 2001-12 |
|
| Randomised comparison of ondansetron plus dexamethasone with dexamethasone alone for the control of delayed cisplatin-induced emesis. | 2001-12 |
|
| Central antiemetic effects of AS-8112, a dopamine D2, D3, and 5-HT(3) receptor antagonist, in ferrets. | 2001-11-23 |
|
| Pharmacological characterization of cyclosporine A-induced kaolin intake in rats. | 2001-11-10 |
|
| Radiation-induced emesis: a problem with many open questions. | 2001-11-06 |
|
| Potent antagonism of 5-HT(3) and 5-HT(6) receptors by olanzapine. | 2001-11-02 |
|
| Failure of ondansetron in treating cerebellar tremor in MS patients--an open-label pilot study. | 2001-11 |
|
| Effective cross-over to granisetron after failure to ondansetron, a randomized double blind study in patients failing ondansetron plus dexamethasone during the first 24 hours following highly emetogenic chemotherapy. | 2001-10-19 |
|
| Anaphylactic reaction to ondansetron. | 2001-10-08 |
|
| [Postoperative nausea--still a problem]. | 2001-10-03 |
|
| Durable treatment-free remission after high-dose cyclophosphamide therapy for previously untreated severe aplastic anemia. | 2001-10-02 |
|
| [Examination on efficacy and safety of concurrent use of ondansetron hydrochloride and steroid in gynecological cancer patients on cisplatin]. | 2001-10 |
|
| Treatment of bulimia nervosa with ondansetron. | 2001-10 |
|
| Drug-induced amnesia is a separate phenomenon from sedation: electrophysiologic evidence. | 2001-10 |
|
| Acupuncture versus ondansetron in the prevention of postoperative vomiting. A study of children undergoing dental surgery. | 2001-10 |
|
| Effects of alosetron on spontaneous migrating motor complexes in murine small and large bowel in vitro. | 2001-10 |
|
| Intestinal serotonin acts as paracrine substance to mediate pancreatic secretion stimulated by luminal factors. | 2001-10 |
|
| Mirtazapine may be useful in treating nausea and insomnia of cancer chemotherapy. | 2001-09 |
|
| Gender discrepancy observed between chemotherapy-induced emesis and hiccups. | 2001-09 |
|
| Comparing the efficacy of prophylactic metoclopramide, ondansetron, and placebo in cesarean section patients given epidural anesthesia. | 2001-09 |
|
| Effect of ondansetron pretreatment on pain after rocuronium and propofol injection: a randomised, double-blind controlled comparison with lidocaine. | 2001-09 |
|
| Prophylactic ondansetron does not improve patient satisfaction in women using PCA after Caesarean section. | 2001-09 |
|
| Antiemetic efficacy of smoked marijuana: subjective and behavioral effects on nausea induced by syrup of ipecac. | 2001-08-18 |
|
| Antagonism of the 5-HT(3) receptor does not alter isoflurane MAC in rats. | 2001-08 |
|
| Does the alcoholic's remedy come in a pill? | 2001-08 |
|
| Delayed nausea and vomiting in children receiving antineoplastics. | 2001-08 |
|
| Postoperative nausea and vomiting in female patients. | 2001-08 |
|
| Ondansetron attenuates CCK induced satiety and c-fos labeling in the dorsal medulla. | 2001-08 |
|
| Effects of TAK-637, a novel neurokinin-1 receptor antagonist, on colonic function in vivo. | 2001-08 |
|
| Comparison of ondansetron-dexamethasone-lorazepam versus metoclopramide-dexamethasone-lorazepam in the control of cisplatin induced emesis. | 2001-07 |
|
| Dexamethasone, paclitaxel, etoposide, cyclophosphamide (d-TEC) and G-CSF for stem cell mobilisation in multiple myeloma. | 2001-07 |
|
| Effects of HSP-117, a novel tachykinin NK1-receptor antagonist, on cisplatin-induced pica as a new evaluation of delayed emesis in rats. | 2001-07 |
|
| [Examination on efficacy and safety of concurrent use of ondansetron hydrochloride and steroid in lung cancer patients on cisplatin]. | 2001-07 |
|
| Outpatient laparoscopic adrenalectomy in patients with Conn's syndrome. | 2001-06 |
|
| Pre-emptive metoclopramide and ondansetron for nausea and vomiting associated with iloprost infusions. | 2001-06 |
|
| Efficacy of single-dose intravenous dolasetron versus ondansetron in the prevention of postoperative nausea and vomiting. | 2001-06 |
|
| Role of various types of serotonin receptors in regulation of drinking behavior and salt appetite in vasopressin-deficient brattleboro rats. | 2001-05 |
|
| The anxiolytic-like effect of MCI-225, a selective NA reuptake inhibitor with 5-HT3 receptor antagonism. | 2001-04 |
|
| Prevention of vomiting after general anesthesia for pediatric ophthalmic surgery. | 2001-02 |
|
| Dexamethasone is a cost-effective alternative to ondansetron in preventing PONV after paediatric strabismus repair. | 2001-01 |
|
| Pruritus. | 2001 |
|
| Prevention of vomiting after strabismus surgery in children: dexamethasone alone versus dexamethasone plus low-dose ondansetron. | 2001 |
|
| The neuropharmacology of upper airway motor control in the awake and asleep states: implications for obstructive sleep apnoea. | 2001 |
|
| Randomized open-label trial of dolasetron for the control of nausea and vomiting associated with high-dose chemotherapy with hematopoietic stem cell transplantation. | 2001 |
|
| Ondansetron: a selective 5-HT(3) receptor antagonist and its applications in CNS-related disorders. | 2001 |
|
| Combination of transcutaneous electrical nerve stimulation and ondansetron in preventing cisplatin-induced emesis. | 2001 |
|
| [Postoperative nausea and vomiting--still a problem?]. | 2001 |
|
| Ondansetron: a review of its use as an antiemetic in children. | 2001 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Apr 02 12:40:17 GMT 2025
by
admin
on
Wed Apr 02 12:40:17 GMT 2025
|
| Record UNII |
RJ5EJS99VH
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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146475-23-2
Created by
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57501259
Created by
admin on Wed Apr 02 12:40:17 GMT 2025 , Edited by admin on Wed Apr 02 12:40:17 GMT 2025
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PRIMARY | |||
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RJ5EJS99VH
Created by
admin on Wed Apr 02 12:40:17 GMT 2025 , Edited by admin on Wed Apr 02 12:40:17 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> SALT/SOLVATE |
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