U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C28H37N5O7
Molecular Weight 555.6227
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LEUCINE ENKEPHALIN

SMILES

CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC2=CC=C(O)C=C2)C(O)=O

InChI

InChIKey=URLZCHNOLZSCCA-VABKMULXSA-N
InChI=1S/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)/t21-,22-,23-/m0/s1

HIDE SMILES / InChI

Molecular Formula C28H37N5O7
Molecular Weight 555.6227
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 3 / 3
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

PubMed

PubMed

TitleDatePubMed
A selective fluorescence reaction for peptides and chromatographic analysis.
2008-03
Translating DNA into synthetic molecules.
2004-07
DNA display III. Solid-phase organic synthesis on unprotected DNA.
2004-07
2',6'-dimethylphenylalanine (Dmp) can mimic the N-terminal Tyr in opioid peptides.
2004-02
Characterization of human nasal primary culture systems to investigate peptide metabolism.
2002-05-15
Identification of dipeptidyl peptidase III in human neutrophils.
2000-07-05
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
1998-03
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
1994-02
Cloning and pharmacological characterization of a rat kappa opioid receptor.
1993-11-01
Inhibition of vagal transmission by cardiac sympathetic nerve stimulation in the dog: possible involvement of opioid receptor.
1989-09
Seizures induced by carbachol, morphine, and leucine-enkephalin: a comparison.
1983-04
Anticonvulsants specific for petit mal antagonize epileptogenic effect of leucine enkephalin.
1980-11-28
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:11:50 GMT 2025
Edited
by admin
on Mon Mar 31 18:11:50 GMT 2025
Record UNII
RI01R707R6
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PENTAPEPTIDE-5
INCI  
INCI  
Preferred Name English
LEUCINE ENKEPHALIN
Common Name English
SH-PENTAPEPTIDE-5
INCI  
INCI  
Preferred Name English
TYR-GLY-GLY-PHE-LEU
Common Name English
ICI-114740
Code English
SM-PEPTIDE-1
Brand Name English
L-LEUCINE, L-TYROSYLGLYCYLGLYCYL-L-PHENYLALANYL-
Systematic Name English
LEU-ENKEPHALIN
Common Name English
NSC-350588
Code English
Code System Code Type Description
PUBCHEM
461776
Created by admin on Mon Mar 31 18:11:50 GMT 2025 , Edited by admin on Mon Mar 31 18:11:50 GMT 2025
PRIMARY
CAS
58822-25-6
Created by admin on Mon Mar 31 18:11:50 GMT 2025 , Edited by admin on Mon Mar 31 18:11:50 GMT 2025
PRIMARY
NSC
350588
Created by admin on Mon Mar 31 18:11:50 GMT 2025 , Edited by admin on Mon Mar 31 18:11:50 GMT 2025
PRIMARY
WIKIPEDIA
LEU-ENKEPHALIN
Created by admin on Mon Mar 31 18:11:50 GMT 2025 , Edited by admin on Mon Mar 31 18:11:50 GMT 2025
PRIMARY
ECHA (EC/EINECS)
261-457-1
Created by admin on Mon Mar 31 18:11:50 GMT 2025 , Edited by admin on Mon Mar 31 18:11:50 GMT 2025
PRIMARY
CHEBI
89656
Created by admin on Mon Mar 31 18:11:50 GMT 2025 , Edited by admin on Mon Mar 31 18:11:50 GMT 2025
PRIMARY
FDA UNII
RI01R707R6
Created by admin on Mon Mar 31 18:11:50 GMT 2025 , Edited by admin on Mon Mar 31 18:11:50 GMT 2025
PRIMARY
EPA CompTox
DTXSID00905127
Created by admin on Mon Mar 31 18:11:50 GMT 2025 , Edited by admin on Mon Mar 31 18:11:50 GMT 2025
PRIMARY