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Details

Stereochemistry MIXED
Molecular Formula C10Cl10O
Molecular Weight 490.636
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CHLORDECONE

SMILES

ClC12C(=O)C3(Cl)C4(Cl)C1(Cl)C5(Cl)C2(Cl)C3(Cl)C4(Cl)C5(Cl)Cl

InChI

InChIKey=LHHGDZSESBACKH-UHFFFAOYSA-N
InChI=1S/C10Cl10O/c11-2-1(21)3(12)6(15)4(2,13)8(17)5(2,14)7(3,16)9(6,18)10(8,19)20

HIDE SMILES / InChI
Molecular Formula C10Cl10O
Molecular Weight 490.636
Charge 0
Count
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 0 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
Estrogenic activity of the insecticide kepone on the chicken oviduct.
1978 Jul 28
Interaction of chlordecone with biological membranes.
1981 Nov-Dec
Preferential binding of chlordecone to the protein and high density lipoprotein fractions of plasma from humans and other species.
1982 Jan
Chlorinated hydrocarbon pesticides and amygdaloid kindling.
1985 May-Jun
Studies on the mechanism of chlordecone-induced tremor in rats.
1985 Spring
Pharmacological modification of DDT-induced tremor and hyperthermia in rats: distributional factors.
1986
Purification and characterization of chlordecone reductase from human liver.
1986 Sep 25
The effects of lindane, DDT, and chlordecone on avoidance responding and seizure activity.
1987 Mar 30
Two polychlorinated hydrocarbons cause phospholipid-dependent protein kinase C activation in vitro in the absence of calcium.
1991
Selective induction of cytochrome P450e by kepone (chlordecone) in primary cultures of adult rat hepatocytes.
1991 Aug
Regulation of cytochrome P450 2B1/2 mRNAs by Kepone (chlordecone) and potent estrogens in primary cultures of adult rat hepatocytes on Matrigel.
1994 Apr
Influence of xenobiotics on rainbow trout liver estrogen receptor and vitellogenin gene expression.
1995 Oct
Pesticides: an important but underused model for the environmental health sciences.
1996 Mar
Kepone (chlordecone).
2004
Mechanistic approaches for mixture risk assessments-present capabilities with simple mixtures and future directions.
2004 Mar
Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption.
2006 Dec
QSAR prediction of estrogen activity for a large set of diverse chemicals under the guidance of OECD principles.
2006 Nov
Effects of possible endocrine disrupting chemicals on bacterial component-induced activation of NF-kappaB.
2006 Oct
Activity of xenoestrogens at nanomolar concentrations in the E-Screen assay.
2007 Dec
Diminished prolactin from chlordecone treatment in ovariectomized (NZBxNZW)F(1) mice.
2007 Dec 15
Effect of sublethal exposure to chlordecone on life history characteristics of freshwater rotifer Brachionus calyciflorus pallas.
2007 Jan
Differential activation of wild-type estrogen receptor alpha and C-terminal deletion mutants by estrogens, antiestrogens and xenoestrogens in breast cancer cells.
2007 Jan
Effects of prenatal chlordecone on sexually differentiated behavior in adult rats.
2007 Mar-Apr
Hepatic sequestration of chlordecone and hexafluoroacetone evaluated by pharmacokinetic modeling.
2007 May 5
Increased level of cellular Bip critically determines estrogenic potency for a xenoestrogen kepone in the mouse uterus.
2007 Oct
Dietary exposure to pesticide residues in Yaoundé: the Cameroonian total diet study.
2008 Apr
[Chlordecone and cancer in French-West Indies].
2008 Aug
Chlordecone, a mixed pregnane X receptor (PXR) and estrogen receptor alpha (ERalpha) agonist, alters cholesterol homeostasis and lipoprotein metabolism in C57BL/6 mice.
2008 Dec 1
Comparison of chlordecone and estradiol effects on splenic T-cells in (NZBxNZW)F(1) mice.
2008 Dec 15
Physiologically based pharmacokinetic modeling of persistent organic pollutants for lifetime exposure assessment: a new tool in breast cancer epidemiologic studies.
2008 Jul
Effects of possible endocrine disruptors on MyD88-independent TLR4 signaling.
2008 Mar
A comparison of relative quantification with isobaric tags on a subset of the murine hepatic proteome using electrospray ionization quadrupole time-of-flight and matrix-assisted laser desorption/ionization tandem time-of-flight.
2008 Oct
Chlordecone increased subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes without altering cytosolic cholesterol binding proteins.
2009 Dec 1
A comparison of the effects of three GM corn varieties on mammalian health.
2009 Dec 10
Long-term pollution by chlordecone of tropical volcanic soils in the French West Indies: a simple leaching model accounts for current residue.
2009 May
Impacts of molt-inhibiting organochlorine compounds on epidermal ecdysteroid signaling in the fiddler crab, Uca pugilator, in vitro.
2009 Nov
Determination of soil content in chlordecone (organochlorine pesticide) using near infrared reflectance spectroscopy (NIRS).
2009 Nov
Exploring the molecular basis of insecticide resistance in the dengue vector Aedes aegypti: a case study in Martinique Island (French West Indies).
2009 Oct 26
Hormonal action of plant derived and anthropogenic non-steroidal estrogenic compounds: phytoestrogens and xenoestrogens.
2010
Elevated AKR1C3 expression promotes prostate cancer cell survival and prostate cell-mediated endothelial cell tube formation: implications for prostate cancer progression.
2010 Dec 6
Pesticide exposure of pregnant women in Guadeloupe: ability of a food frequency questionnaire to estimate blood concentration of chlordecone.
2010 Feb
Comparison of relative binding affinities to fish and mammalian estrogen receptors: the regulatory implications.
2010 Feb 15
Chlordecone exposure and risk of prostate cancer.
2010 Jul 20
[Endocrine disruptors: are they carcinogens?].
2010 Jun
Non-communicable diseases in sub-Saharan Africa: the case for cohort studies.
2010 May 11
Current status and regulatory aspects of pesticides considered to be persistent organic pollutants (POPs) in Taiwan.
2010 Oct
Differential responses to retinoic acid and endocrine disruptor compounds of subpopulations within human embryonic stem cell lines.
2012 Nov
Endocrine-Disrupting Chemicals (EDCs): In Vitro Mechanism of Estrogenic Activation and Differential Effects on ER Target Genes.
2013 Apr
Regulation of hepatic drug transporter activity and expression by organochlorine pesticides.
2014 Mar
Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study.
2015 May
Substance Class Chemical
Created
by admin
on Fri Dec 15 14:59:48 GMT 2023
Edited
by admin
on Fri Dec 15 14:59:48 GMT 2023
Record UNII
RG5XJ88UDF
Record Status Validated (UNII)
Record Version
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Name Type Language
CHLORDECONE
HSDB   ISO   MI  
Common Name English
CHLORDECONE [ISO]
Common Name English
GC-1189
Brand Name English
DECACHLOROKETONE
Common Name English
NSC-56532
Code English
NSC-124074
Code English
CLORDECONE
Common Name English
CHLORDECONE [MI]
Common Name English
CHLORDECONE [IARC]
Common Name English
CHLORDECONE [HSDB]
Common Name English
KEPONE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C45410
Created by admin on Fri Dec 15 14:59:48 GMT 2023 , Edited by admin on Fri Dec 15 14:59:48 GMT 2023
EPA PESTICIDE CODE 27701
Created by admin on Fri Dec 15 14:59:48 GMT 2023 , Edited by admin on Fri Dec 15 14:59:48 GMT 2023
Code System Code Type Description
PUBCHEM
299
Created by admin on Fri Dec 15 14:59:49 GMT 2023 , Edited by admin on Fri Dec 15 14:59:49 GMT 2023
PRIMARY
HSDB
1558
Created by admin on Fri Dec 15 14:59:48 GMT 2023 , Edited by admin on Fri Dec 15 14:59:48 GMT 2023
PRIMARY
NCI_THESAURUS
C44352
Created by admin on Fri Dec 15 14:59:48 GMT 2023 , Edited by admin on Fri Dec 15 14:59:48 GMT 2023
PRIMARY
WIKIPEDIA
KEPONE
Created by admin on Fri Dec 15 14:59:49 GMT 2023 , Edited by admin on Fri Dec 15 14:59:49 GMT 2023
PRIMARY
FDA UNII
RG5XJ88UDF
Created by admin on Fri Dec 15 14:59:48 GMT 2023 , Edited by admin on Fri Dec 15 14:59:48 GMT 2023
PRIMARY
CHEBI
16548
Created by admin on Fri Dec 15 14:59:48 GMT 2023 , Edited by admin on Fri Dec 15 14:59:48 GMT 2023
PRIMARY
MESH
D007631
Created by admin on Fri Dec 15 14:59:48 GMT 2023 , Edited by admin on Fri Dec 15 14:59:48 GMT 2023
PRIMARY
CAS
143-50-0
Created by admin on Fri Dec 15 14:59:48 GMT 2023 , Edited by admin on Fri Dec 15 14:59:48 GMT 2023
PRIMARY
NSC
56532
Created by admin on Fri Dec 15 14:59:49 GMT 2023 , Edited by admin on Fri Dec 15 14:59:49 GMT 2023
PRIMARY
MERCK INDEX
m3354
Created by admin on Fri Dec 15 14:59:48 GMT 2023 , Edited by admin on Fri Dec 15 14:59:48 GMT 2023
PRIMARY Merck Index
ALANWOOD
chlordecone
Created by admin on Fri Dec 15 14:59:48 GMT 2023 , Edited by admin on Fri Dec 15 14:59:48 GMT 2023
PRIMARY
EPA CompTox
DTXSID1020770
Created by admin on Fri Dec 15 14:59:48 GMT 2023 , Edited by admin on Fri Dec 15 14:59:48 GMT 2023
PRIMARY
NSC
124074
Created by admin on Fri Dec 15 14:59:49 GMT 2023 , Edited by admin on Fri Dec 15 14:59:49 GMT 2023
PRIMARY
ECHA (EC/EINECS)
205-601-3
Created by admin on Fri Dec 15 14:59:48 GMT 2023 , Edited by admin on Fri Dec 15 14:59:48 GMT 2023
PRIMARY
Related Record Type Details
Structure of CHLORDECONE ALCOHOL
METABOLITE -> PARENT
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