CHLORDECONE

Details

Stereochemistry	MIXED
Molecular Formula	C10Cl10O
Molecular Weight	490.636
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC12C(=O)C3(Cl)C4(Cl)C1(Cl)C5(Cl)C2(Cl)C3(Cl)C4(Cl)C5(Cl)Cl

InChI

InChIKey=LHHGDZSESBACKH-UHFFFAOYSA-N

InChI=1S/C10Cl10O/c11-2-1(21)3(12)6(15)4(2,13)8(17)5(2,14)7(3,16)9(6,18)10(8,19)20

HIDE SMILES / InChI

Molecular Formula	C10Cl10O
Molecular Weight	490.636
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study.	2015-05	25622337
Regulation of hepatic drug transporter activity and expression by organochlorine pesticides.	2014-03	24464585
Endocrine-Disrupting Chemicals (EDCs): In Vitro Mechanism of Estrogenic Activation and Differential Effects on ER Target Genes.	2013-04	23384675
Differential responses to retinoic acid and endocrine disruptor compounds of subpopulations within human embryonic stem cell lines.	2012-11	22906706
Elevated AKR1C3 expression promotes prostate cancer cell survival and prostate cell-mediated endothelial cell tube formation: implications for prostate cancer progression.	2010-12-06	21134280
Current status and regulatory aspects of pesticides considered to be persistent organic pollutants (POPs) in Taiwan.	2010-10	21139852
Chlordecone exposure and risk of prostate cancer.	2010-07-20	20566993
[Endocrine disruptors: are they carcinogens?].	2010-06	21513143
Non-communicable diseases in sub-Saharan Africa: the case for cohort studies.	2010-05-11	20485489
Comparison of relative binding affinities to fish and mammalian estrogen receptors: the regulatory implications.	2010-02-15	19913605
Pesticide exposure of pregnant women in Guadeloupe: ability of a food frequency questionnaire to estimate blood concentration of chlordecone.	2010-02	20003965
Hormonal action of plant derived and anthropogenic non-steroidal estrogenic compounds: phytoestrogens and xenoestrogens.	2010	20738246
A comparison of the effects of three GM corn varieties on mammalian health.	2009-12-10	20011136
Chlordecone increased subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes without altering cytosolic cholesterol binding proteins.	2009-12-01	19666090
Impacts of molt-inhibiting organochlorine compounds on epidermal ecdysteroid signaling in the fiddler crab, Uca pugilator, in vitro.	2009-11	19567274
Determination of soil content in chlordecone (organochlorine pesticide) using near infrared reflectance spectroscopy (NIRS).	2009-11	19493598
Exploring the molecular basis of insecticide resistance in the dengue vector Aedes aegypti: a case study in Martinique Island (French West Indies).	2009-10-26	19857255
Long-term pollution by chlordecone of tropical volcanic soils in the French West Indies: a simple leaching model accounts for current residue.	2009-05	19167793
Comparison of chlordecone and estradiol effects on splenic T-cells in (NZBxNZW)F(1) mice.	2008-12-15	18951962
Chlordecone, a mixed pregnane X receptor (PXR) and estrogen receptor alpha (ERalpha) agonist, alters cholesterol homeostasis and lipoprotein metabolism in C57BL/6 mice.	2008-12-01	18789348
A comparison of relative quantification with isobaric tags on a subset of the murine hepatic proteome using electrospray ionization quadrupole time-of-flight and matrix-assisted laser desorption/ionization tandem time-of-flight.	2008-10	18798194
[Chlordecone and cancer in French-West Indies].	2008-08	18692333
Parallel assessment of male reproductive function in workers and wild rats exposed to pesticides in banana plantations in Guadeloupe.	2008-07-30	18667078
Physiologically based pharmacokinetic modeling of persistent organic pollutants for lifetime exposure assessment: a new tool in breast cancer epidemiologic studies.	2008-07	18629310
Chlordecone altered hepatic disposition of [14C]cholesterol and plasma cholesterol distribution but not SR-BI or ABCG8 proteins in livers of C57BL/6 mice.	2008-06-15	18387646
Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens.	2008-05	18400491
Dietary exposure to pesticide residues in Yaoundé: the Cameroonian total diet study.	2008-04	18348045
Effects of possible endocrine disruptors on MyD88-independent TLR4 signaling.	2008-03	18177342
Diminished prolactin from chlordecone treatment in ovariectomized (NZBxNZW)F(1) mice.	2007-12-15	17996692
Activity of xenoestrogens at nanomolar concentrations in the E-Screen assay.	2007-12	18174956
Increased level of cellular Bip critically determines estrogenic potency for a xenoestrogen kepone in the mouse uterus.	2007-10	17640991
Impact of subsistence production on the management options to reduce the food exposure of the Martinican population to Chlordecone.	2007-10	17576028
Acceleration of autoimmunity by organochlorine pesticides: a comparison of splenic B-cell effects of chlordecone and estradiol in (NZBxNZW)F1 mice.	2007-09	17578864
Cytotoxic effects and aromatase inhibition by xenobiotic endocrine disrupters alone and in combination.	2007-07-15	17599374
Hepatic sequestration of chlordecone and hexafluoroacetone evaluated by pharmacokinetic modeling.	2007-05-05	17382449
Effect of sublethal exposure to chlordecone on life history characteristics of freshwater rotifer Brachionus calyciflorus pallas.	2007-01	17364244
Mechanistic approaches for mixture risk assessments-present capabilities with simple mixtures and future directions.	2004-03	21782689
Kepone (chlordecone).	2004	21089898
Pesticides: an important but underused model for the environmental health sciences.	1996-03	8722114
Influence of xenobiotics on rainbow trout liver estrogen receptor and vitellogenin gene expression.	1995-10	8800639
Regulation of cytochrome P450 2B1/2 mRNAs by Kepone (chlordecone) and potent estrogens in primary cultures of adult rat hepatocytes on Matrigel.	1994-04	7513451
Two polychlorinated hydrocarbons cause phospholipid-dependent protein kinase C activation in vitro in the absence of calcium.	1991	1724372
The effects of lindane, DDT, and chlordecone on avoidance responding and seizure activity.	1987-03-30	2436354
Purification and characterization of chlordecone reductase from human liver.	1986-09-25	2427522
Pharmacological modification of DDT-induced tremor and hyperthermia in rats: distributional factors.	1986	3088650
Chlorinated hydrocarbon pesticides and amygdaloid kindling.	1985-05-01	2412143
Studies on the mechanism of chlordecone-induced tremor in rats.	1985	2581196
Preferential binding of chlordecone to the protein and high density lipoprotein fractions of plasma from humans and other species.	1982-01	6174734
Interaction of chlordecone with biological membranes.	1981-11-01	6175765
Estrogenic activity of the insecticide kepone on the chicken oviduct.	1978-07-28	78523

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:34:30 GMT 2025` Edited by `admin` on `Mon Mar 31 17:34:30 GMT 2025`
Record UNII	RG5XJ88UDF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GC-1189

Preferred Name

English

CHLORDECONE

Common Name

English

CHLORDECONE [ISO]

Common Name

English

DECACHLOROKETONE

Common Name

English

NSC-56532

Code

English

NSC-124074

Code

English

CLORDECONE

Common Name

English

CHLORDECONE [MI]

Common Name

English

CHLORDECONE [IARC]

Common Name

English

CHLORDECONE [HSDB]

Common Name

English

KEPONE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C45410