FOSFOCREATININE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C4H8N3O4P
Molecular Weight	193.0978
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CC(=O)N=C1NP(O)(O)=O

InChI

InChIKey=HIPLEPXPNLWKCQ-UHFFFAOYSA-N

InChI=1S/C4H8N3O4P/c1-7-2-3(8)5-4(7)6-12(9,10)11/h2H2,1H3,(H3,5,6,8,9,10,11)

HIDE SMILES / InChI

Molecular Formula	C4H8N3O4P
Molecular Weight	193.0978
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.genome.jp/dbget-bin/www_bget?drug+D07163

Fosfocreatinine, a cardioprotectant that was used for the treatment of cardiac disorders. Information about the current use of this drug is not available.

Approval Year

PubMed

Title	Date	PubMed
Initial experiences with proton MR spectroscopy in treatment monitoring of mitochondrial encephalopathy.	2010-09	20635440
Asymmetric excitatory synaptic dynamics underlie interaural time difference processing in the auditory system.	2010-06-29	20613857
Slope-based stochastic resonance: how noise enables phasic neurons to encode slow signals.	2010-06-24	20585612
Diverse antiepileptic drugs increase the ratio of background synaptic inhibition to excitation and decrease neuronal excitability in neurones of the rat entorhinal cortex in vitro.	2010-05-05	20167261
Mechanism of post-translational modification by tyrosine phosphorylation of apoptotic proteins during hypoxia in the cerebral cortex of newborn piglets.	2010-01	19597709
Pathogenesis of insulin resistance in skeletal muscle.	2010	20445742
Multifactorial determinants of functional capacity in peripheral arterial disease: uncoupling of calf muscle perfusion and metabolism.	2009-08-11	19660694
Foot muscle energy reserves in diabetic patients without and with clinical peripheral neuropathy.	2009-08	19509013
Replication independent formation of extrachromosomal circular DNA in mammalian cell-free system.	2009-07-01	19568438
AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease.	2009-04	19275766
Characteristics, correlates, and outcomes of childhood and adolescent depressive disorders.	2009	19432387
Effect of hypoxia on the expression of procaspase-9 and procaspase-3 in neuronal nuclear, mitochondrial and cytosolic fractions of the cerebral cortex of newborn piglets.	2008-06-13	18468794
The role of NMDA receptor subtypes in short-term plasticity in the rat entorhinal cortex.	2008	18989370
Phosphorylation potential in the dominant leg is lower, and [ADPfree] is higher in calf muscles at rest in endurance athletes than in sprinters and in untrained subjects.	2007-12	18195489
Impact of exercise capacity on myocardial high-energy phosphate metabolism.	2007-08	17455117
Conditions of wound healing and cutaneous growth affect metabolic performance of skin following plastic surgery.	2007-07-26	17650092
The relationship between the VO2 slow component, muscle metabolites and performance during very-heavy exhaustive exercise.	2007-06	16890488
Massage therapy for cancer patients: a reciprocal relationship between body and mind.	2007-04	17576465
A novel relationship between creatine transport at the blood-brain and blood-retinal barriers, creatine biosynthesis, and its use for brain and retinal energy homeostasis.	2007	18652073
Evidence of brain mitochondrial activities after oxygen inhalation by 31P magnetic resonance spectroscopy at 3T.	2007	18002601
Hypoxia-induced Bax and Bcl-2 protein expression, caspase-9 activation, DNA fragmentation, and lipid peroxidation in mitochondria of the cerebral cortex of newborn piglets: the role of nitric oxide.	2006-09-01	16777344
Effect of neuronal nitric oxide synthase inhibition on caspase-9 activity during hypoxia in the cerebral cortex of newborn piglets.	2006-06-19	16545906
Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction.	2006-03-31	16410253
A selective inhibitor of Na+/Ca2+ exchanger, SEA0400, preserves cardiac function and high-energy phosphates against ischemia/reperfusion injury.	2006-02	16495765
Phosphorous-31 magnetic resonance spectroscopy of cervical cancer using transvaginal surface coil.	2005-12-31	16543705
Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents.	2005-09	16089501
High-energy phosphate metabolism in the calf muscle during moderate isotonic exercise under different degrees of cuff compression: a phosphorus 31 magnetic resonance spectroscopy study.	2005-08	16102624
Effects of alpha-phenyl-N-tert-butyl nitrone (PBN)on brain cell membrane function and energy metabolism during transient global cerebral hypoxia-ischemia and reoxygenation-reperfusion in newborn piglets.	2004-06	15201509
Abnormal mitochondrial function and muscle wasting, but normal contractile efficiency, in haemodialysed patients studied non-invasively in vivo.	2004-06	15004250
Oxygen and the diving seal.	2004	15233163
Potential of phosphorus nuclear magnetic resonance spectroscopy in studies of the energy metabolism of skeletal muscles.	2003-09	14552542
Proton magnetic resonance spectroscopy of bipolar disorder versus intermittent explosive disorder in children and adolescents.	2003-08	12900307
Proton MRS profile of cerebral metabolic abnormalities in Krabbe disease.	2003-03-11	12629240
Effects of epinephrine and norepinephrine on hemodynamics, oxidative metabolism, and organ energetics in endotoxemic rats.	2003-02	12594589
[Effects of metabolic substrates and mannitol on efficiency of cardioplegic protection in isolated rat heart].	2003	12891289
Fast imaging of phosphocreatine in the normal human myocardium using a three-dimensional RARE pulse sequence at 4 Tesla.	2002-04	11948837
[Phosphorus magnetic resonance in studying energy metabolism in skeletal muscles].	2002-03	12013729
Pyruvate/dichloroacetate supply during reperfusion accelerates recovery of cardiac energetics and improves mechanical function following cardioplegic arrest.	2001-06	11404144
Role of creatine kinase isoenzymes on muscular and cardiorespiratory endurance: genetic and molecular evidence.	2001	11708401

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:28:41 GMT 2025` Edited by `admin` on `Mon Mar 31 18:28:41 GMT 2025`
Record UNII	RG2371KXDE
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FOSFOCREATININE

Official Name

English

FOSFOCREATININE [MART.]

Preferred Name

English

(1-METHYL-4-OXO-2-IMIDAZOLIDINYLIDENE)PHOSPHORAMIDIC ACID

Systematic Name

English

fosfocreatinine [INN]

Common Name

English

Fosfocreatinine [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29396