Hydroxypropyl cellulose (HPC) is an ether of cellulose where some of the hydroxyl groups of the cellulose have been hydroxypropylated. Hydroxypropyl cellulose is used as an excipient, and topical ophthalmic protectant and lubricant. Hydroxypropyl cellulose, manufactured by Aton Pharma, is a formulation of HPC used for artificial tears. It is used to treat medical conditions characterized by insufficient tear production such as keratoconjunctivitis sicca), recurrent corneal erosions, decreased corneal sensitivity, exposure, and neuroparalytic keratitis. HPC is also used as a lubricant for artificial eyes. Hydroxypropyl cellulose acts to stabilize and thicken the precorneal tear film and prolong the tear film breakup time which is usually accelerated in patients with dry eye states. Hydroxypropyl cellulose usually reduces the signs and symptoms resulting from moderate to severe dry eye syndromes, such as conjunctival hyperemia, corneal and conjunctival staining with rose bengal, exudation, itching, burning, foreign body sensation, smarting, photophobia, dryness, and blurred and cloudy vision. Progression visual deterioration which occurs in some patients may be retarded, halted, or sometimes reversed.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: the precorneal tear film |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | LACRISERT Approved UseLACRISERT is indicated in patients with moderate to severe dry eye syndromes, including keratoconjunctivitis sicca. LACRISERT is indicated especially in patients who remain symptomatic after an adequate trial of therapy with artificial tear solutions.
LACRISERT is also indicated for patients with:
Exposure keratitis
Decreased corneal sensitivity
Recurrent corneal erosions Launch Date1981 |
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| Primary | LACRISERT Approved UseLACRISERT is indicated in patients with moderate to severe dry eye syndromes, including keratoconjunctivitis sicca. LACRISERT is indicated especially in patients who remain symptomatic after an adequate trial of therapy with artificial tear solutions.
LACRISERT is also indicated for patients with:
Exposure keratitis
Decreased corneal sensitivity
Recurrent corneal erosions Launch Date1981 |
|||
| Primary | LACRISERT Approved UseLACRISERT is indicated in patients with moderate to severe dry eye syndromes, including keratoconjunctivitis sicca. LACRISERT is indicated especially in patients who remain symptomatic after an adequate trial of therapy with artificial tear solutions.
LACRISERT is also indicated for patients with:
Exposure keratitis
Decreased corneal sensitivity
Recurrent corneal erosions Launch Date1981 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| A combination of hydroxypropyl cellulose and trehalose as supplementation for vitrification of human oocytes: a retrospective cohort study. | 2016-03 |
|
| Randomised clinical trial: colestyramine vs. hydroxypropyl cellulose in patients with functional chronic watery diarrhoea. | 2015-06 |
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| Efficacy of hydroxypropyl cellulose ophthalmic inserts (LACRISERT) in subsets of patients with dry eye syndrome: findings from a patient registry. | 2010-12 |
|
| Performance of a hydroxypropyl cellulose film former in normal and ulcerated oral mucosa. | 1988-06 |
Patents
Sample Use Guides
One LACRISERT ophthalmic insert (5mg/insert) in each eye once daily
Route of Administration:
Topical
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12622396
Polymer solutions were prepared incrementally, increasing polymer (HPC) concentration by 0.5% per increment (w/v) between 1.0% and 5.0%. A stock solution containing 1 M MES and 0.5 M TRIS (pH 6.1) was prepared and utilized for all buffers throughout the experiments.
| Substance Class |
Polymer
Created
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| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
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| MOL_WEIGHT:NUMBER AVERAGE | CHEMICAL |
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| MOL_WEIGHT:WEIGHT AVERAGE | CHEMICAL |
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| DEGREE OF SUBSTITUTION | CHEMICAL |
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HYDROXYPROPYL FRAGMENT
(not present in database)
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| MOLAR SUBSTITUTION | CHEMICAL |
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HYDROXYPROPYL FRAGMENT
(not present in database)
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