Rolziracetam (CI-911) is a nootropic drug. In several animal species (monkey, dogs, and rats) it was found to be rapidly eliminated from the body with a half-life of less than 25 min. Rolziracetam improved performance on a delayed-response task in aged rhesus monkeys. The drug was ineffective in a scopolamine-induced amnesia mouse model, in contrast to other nootropic drugs. Development of this piracetam-type cognitive enhancer was terminated.