PRALUZATAMAB RAVTANSINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 09:27:55 GMT 2025` Edited by `admin` on `Wed Apr 02 09:27:55 GMT 2025`
Protein Type	PROBODY
Protein Sub Type	TOXIN CONJUGATE
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	RD2I59M9FC
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CX-2009

Preferred Name

English

PRALUZATAMAB RAVTANSINE

Official Name

English

PRALUZATAMAB RAVTANSINE [USAN]

Common Name

English

praluzatamab ravtansine [INN]

Common Name

English

Praluzatamab ravtansine [WHO-DD]

Common Name

English

IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS CD166 ANTIGEN (ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE)); HUMANIZED MONOCLONAL ANTIBODY; .GAMMA.1 HEAVY CHAIN HUMANIZED (1-450) (VH (HOMO SAPIENS IGHV2-5*01 (89%) (IGHD)-IGHJ4*01 (93%)) (10.7.13) (1-121)-HOM

Common Name

English

ANTI-CD166 PROBODY-DRUG CONJUGATE CX-2009

Common Name

English

ANTI-CD166-DM4 CX-2009

Common Name

English

Code System Code Type Description

CAS

2145115-85-9

Created by admin on Wed Apr 02 09:27:55 GMT 2025 , Edited by admin on Wed Apr 02 09:27:55 GMT 2025

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NCI_THESAURUS

C134697

Created by admin on Wed Apr 02 09:27:55 GMT 2025 , Edited by admin on Wed Apr 02 09:27:55 GMT 2025

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FDA UNII

RD2I59M9FC

Created by admin on Wed Apr 02 09:27:55 GMT 2025 , Edited by admin on Wed Apr 02 09:27:55 GMT 2025

PRIMARY

INN

10939

Created by admin on Wed Apr 02 09:27:55 GMT 2025 , Edited by admin on Wed Apr 02 09:27:55 GMT 2025

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SMS_ID

300000010792

Created by admin on Wed Apr 02 09:27:55 GMT 2025 , Edited by admin on Wed Apr 02 09:27:55 GMT 2025

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USAN

HI-169

Created by admin on Wed Apr 02 09:27:55 GMT 2025 , Edited by admin on Wed Apr 02 09:27:55 GMT 2025

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From	To
1_22	1_97
1_148	1_204
1_224	3_270
1_230	2_230
1_233	2_233
1_265	1_325
1_371	1_429
2_22	2_97
2_148	2_204
2_224	4_270
2_265	2_325
2_371	2_429
3_9	3_20
3_74	3_144
4_9	4_20
4_74	4_144
3_190	3_250
4_190	4_250

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_301
N	2_301

Related Record Type Details


					6MDF4WB915

DM4-SPDB-L-LYSINE

CONJUGATE COMPONENT->CONJUGATE

Amount:


					WB7H35ST8W

MATRIX METALLOPROTEINASE-14

METABOLIC ENZYME -> SUBSTRATE

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1] [3_1] [4_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42
AMINO_ACID_SUBSTITUTION	[1_5] [1_13] [1_66] [1_137] [1_209] [1_214] [1_218] [1_226] [1_250] [1_252] [1_278] [1_292] [1_294] [1_321] [1_326] [1_330] [1_338] [1_364] [1_396] [1_418] [2_5] [2_13] [2_66] [2_137] [2_209] [2_214] [2_218] [2_226] [2_250] [2_252] [2_278] [2_292] [2_294] [2_321] [2_326] [2_330] [2_338] [2_364] [2_396] [2_418] [3_130] [3_163] [3_201] [3_239] [3_244] [3_246] [3_263] [4_130] [4_163] [4_201] [4_239] [4_244] [4_246] [4_263]	RESIDUE_SPECIFIC		Amount:	DM4-SPDB-L-LYSINE	6MDF4WB915

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL