LEFLUTROZOLE

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H10FN5
Molecular Weight	303.2932
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC(N1C=NC=N1)(C2=CC=C(C=C2)C#N)C3=CC=C(C=C3)C#N

InChI

InChIKey=PZDLRBUQYWMNBR-UHFFFAOYSA-N

InChI=1S/C17H10FN5/c18-17(23-12-21-11-22-23,15-5-1-13(9-19)2-6-15)16-7-3-14(10-20)4-8-16/h1-8,11-12H

HIDE SMILES / InChI

Molecular Formula	C17H10FN5
Molecular Weight	303.2932
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9654648 | https://www.ncbi.nlm.nih.gov/pubmed/9310256 | https://www.ncbi.nlm.nih.gov/pubmed/9365186

CGP-47645 (also known as Leflutrozole) is an orally active non-steroidal aromatase aromatase inhibitor which is under development by Mereo BioPharma and Novartis for the treatment of hypogonadism in men.

Originator

Approval Year

PubMed

Title	Date	PubMed
Effect of long-term treatment with aromatase inhibitor on testicular function of adult male bonnet monkeys (M. radiata).	1998 Jul-Aug	9654648

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:56:45 GMT 2025` Edited by `admin` on `Mon Mar 31 18:56:45 GMT 2025`
Record UNII	RCX0IE6EJZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CGP 47,645

Preferred Name

English

LEFLUTROZOLE

Official Name

English

4,4'-(FLUORO-1H-1,2,4-TRIAZOL-1-YLMETHYLENE)BISBENZONITRILE

Systematic Name

English

CGP-47645

Common Name

English

leflutrozole [INN]

Common Name

English

Leflutrozole [WHO-DD]

Common Name

English

Code System Code Type Description

FDA UNII

RCX0IE6EJZ