3,5-Dihydroxy-2-naphthoic acid

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H8O4
Molecular Weight	204.1788
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of 3,5-Dihydroxy-2-naphthoic acid

Structure Search

SMILES

OC(=O)C1=CC2=C(C=C1O)C(O)=CC=C2

InChI

InChIKey=YELLAPKUWRTITI-UHFFFAOYSA-N

InChI=1S/C11H8O4/c12-9-3-1-2-6-4-8(11(14)15)10(13)5-7(6)9/h1-5,12-13H,(H,14,15)

HIDE SMILES / InChI

Molecular Formula	C11H8O4
Molecular Weight	204.1788
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Potency
Ionotropic glutamate receptor NMDA 1/2D 2 Target ID: CHEMBL3038505 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20858708	Positive Allosteric Modulator 186
Glutamate [NMDA] receptor subunit epsilon 1 2 Target ID: CHEMBL1972 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20858708	Negative Allosteric Modulator 43	9.7 µM [IC50]
Glutamate [NMDA] receptor subunit epsilon 2 13 Target ID: CHEMBL1904 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20858708	Negative Allosteric Modulator 43	9.4 µM [IC50]
Glutamate [NMDA] receptor subunit epsilon 3 1 Target ID: CHEMBL4109 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20858708	Negative Allosteric Modulator 43	15.0 µM [IC50]

PubMed

Title	Date	PubMed
Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators.	2012-09	22269804
A novel family of negative and positive allosteric modulators of NMDA receptors.	2010-12	20858708

Substance Class	Chemical Created by `admin` on `Tue Apr 01 18:02:27 GMT 2025` Edited by `admin` on `Tue Apr 01 18:02:27 GMT 2025`
Record UNII	RCB7DWP5NB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

3,5-Dihydroxy-2-naphthoic acid

Systematic Name

English

NSC-50694

Preferred Name

English

3,5-Dihydroxy-2-carboxynaphthalene

Systematic Name

English

3,5-Dihydroxy-2-naphthalenecarboxylic acid

Systematic Name

English

2,8-Dihydroxy-3-naphthoic acid

Systematic Name

English

2-Naphthoic acid, 3,5-dihydroxy-

Systematic Name

English

1,7-Dihydroxy-6-naphthoic acid

Systematic Name

English

2,8-Dihydroxynaphthalene-3-carboxylic acid

Systematic Name

English

1,7-Dihydroxy-6-naphthalenecarboxylic acid

Systematic Name

English

2-Naphthalenecarboxylic acid, 3,5-dihydroxy-

Systematic Name

English

Code System Code Type Description

FDA UNII

RCB7DWP5NB