Ciletatug

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 20:47:51 GMT 2025` Edited by `admin` on `Wed Apr 02 20:47:51 GMT 2025`
Protein Type	MITOCHONDRIAL PROTEIN
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	RAZ26CB689
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Ciletatug

Common Name

English

H-gamma1 heavy chain humanized (1-449) [VH (Homo sapiens IGHV1-46*01 (86.7%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1-119) -Homo sapiens IGHG1*03v (100%) G1m3>G1m17, nG1m1, CH1 K120, CH3 E12, M14 (CH1 R120>K (216) (120-217),

Preferred Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens CLDN18 (claudin 18, claudin-18, surfactant associated protein J, SFTPJ) isoform 2], humanized monoclonal antibody (Ciletatug)

Common Name

English

Immunoglobulin G1, anti-(human/Macaca fascicularis/Mus musculus/Canis familiaris/Rattus norvegicus claudin CLDN18.2) (human-Mus musculus monoclonal RC118-B186314B11S ?1-chain), disulfide with human-Mus musculus monoclonal RC118-B186314B11S ?-chain, dimer

Common Name

English

ciletatug [INN]

Common Name

English

Code System Code Type Description

SMS_ID

300000056822

Created by admin on Wed Apr 02 20:47:51 GMT 2025 , Edited by admin on Wed Apr 02 20:47:51 GMT 2025

PRIMARY

INN

13112

Created by admin on Wed Apr 02 20:47:51 GMT 2025 , Edited by admin on Wed Apr 02 20:47:51 GMT 2025

PRIMARY

FDA UNII

RAZ26CB689

Created by admin on Wed Apr 02 20:47:51 GMT 2025 , Edited by admin on Wed Apr 02 20:47:51 GMT 2025

PRIMARY

CAS

2897622-41-0

Created by admin on Wed Apr 02 20:47:51 GMT 2025 , Edited by admin on Wed Apr 02 20:47:51 GMT 2025

PRIMARY

NCI_THESAURUS

C211800

Created by admin on Wed Apr 02 20:47:51 GMT 2025 , Edited by admin on Wed Apr 02 20:47:51 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_146	2_202
2_222	4_220
2_263	2_323
1_146	1_202
2_369	2_427
3_23	3_94
3_140	3_200
4_23	4_94
4_140	4_200
1_222	3_220
1_228	2_228
1_231	2_231
1_263	1_323
1_369	1_427

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_299
N	2_299

Related Record Type Details


					7ER98K4WW9

Ciletatug Vedotin

CONJUGATE -> PARENT

Amount:


					O86SW5D7BQ

CLAUDIN 18 SPLICE VARIANT 2

TARGET->LIGAND

Amount:

Related Record Type Details


					RAZ26CB689

Ciletatug

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q		PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_449] [2_449]	C-TERMINUS	K		LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL