| Stereochemistry | ACHIRAL |
| Molecular Formula | C4H10O4 |
| Molecular Weight | 122.1198 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC[C@H](O)[C@H](O)CO
InChI
InChIKey=UNXHWFMMPAWVPI-ZXZARUISSA-N
InChI=1S/C4H10O4/c5-1-3(7)4(8)2-6/h3-8H,1-2H2/t3-,4+
| Molecular Formula | C4H10O4 |
| Molecular Weight | 122.1198 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Erythritol is a four carbon sugar that is found in algae, fungi, and lichens. It is twice as sweet as sucrose and has been approved by the United States and EU Food and Drug Administrations for use as a low-calorie sweetener. Erythritol is well tolerated and elicits no toxicological effects. It is rapidly absorbed and quantitatively excreted without metabolic change. Erythritol has been investigated as a food supplement to treat Endothelial Function related to Type II diabetes. It has also been studied for the prevention of gingivitis and carries.
CNS Activity
Originator
Approval Year
PubMed
Patents
Sample Use Guides
Patients with type two diabetes mellitus consumed an orange flavored beverage in three separate sessions with a dose of 6, 12 and 18 grams respectively. Endothelial function was assessed before and two hours after consumption by measuring the change in pulse amplitude in response to reactive hyperemia.
Route of Administration:
Oral
Biofilms were inoculated with stimulated saliva from healthy donors and grown in a gingivitis model in the continuous presence of 0%, 5%, and 10% erythritol. Biofilms were incubated for 9 days and then analyzed for protease activity, and microbial profile. Biofilm growth was significantly reduced in the presence of erythritol in a dose-dependent manner. Protease activity and the diversity of microbial profiles were also significantly lower. The microbial profile revealed that erythritol induced a compositional shift from periodontitis and gingivitis related taxa toward early colonizers.