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Details

Stereochemistry UNKNOWN
Molecular Formula C19H25NO
Molecular Weight 283.4079
Optical Activity ( + )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DROBULINE, (+)-

SMILES

CC(C)NCC(O)CC(C1=CC=CC=C1)C2=CC=CC=C2

InChI

InChIKey=DAIZVBCVNQSHLI-UHFFFAOYSA-N
InChI=1S/C19H25NO/c1-15(2)20-14-18(21)13-19(16-9-5-3-6-10-16)17-11-7-4-8-12-17/h3-12,15,18-21H,13-14H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C19H25NO
Molecular Weight 283.4079
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

Drobuline is a potent cardiac depressant (anti-arrhythmic) agent, which has been found to be effective against ventricular arrhythmias in dogs. This compound is a racemic mixture having a single center of optical activity. The two isomers of drobuline were found to be equally potent in converting cardiac arrhythmias in dogs after intravenous administration. The major route of biotransformation of drobuline in the dog was shown to be conjugation with glucuronic acid.

Approval Year

PubMed

Sample Use Guides

In Vivo Use Guide
Single dose - 10 mg/kg
Route of Administration: Oral
Substance Class Chemical
Record UNII
R97AZJ8FZL
Record Status Validated (UNII)
Record Version