AXATILIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 13:30:15 UTC 2023` Edited by `admin` on `Sat Dec 16 13:30:15 UTC 2023`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	R96Z451BMC
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

AXATILIMAB

Official Name

English

SNDX6352

Code

English

IMMUNOGLOBULIN G4, ANTI-(HUMAN COLONY-STIMULATING FACTOR 1 RECEPTOR) (HUMAN-RATTUS NORVEGICUS MONOCLONAL SNDX-6352 .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN-RATTUS NORVEGICUS MONOCLONAL SNDX-6352 .KAPPA.-CHAIN, DIMER

Common Name

English

SNDX-6352

Code

English

Axatilimab [WHO-DD]

Common Name

English

axatilimab [INN]

Common Name

English

ANTI-CSF1R MONOCLONAL ANTIBODY SNDX-6352

Common Name

English

AXATILIMAB [USAN]

Common Name

English

UCB-6352

Code

English

UCB6352

Code

English

IMMUNOGLOBULIN G4-KAPPA, ANTI-(HOMO SAPIENS MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR (PROTO-ONCOGENE C-FMS; CSF-1-R; CD115_ANTIGEN)); HUMANIZED MONOCLONAL ANTIBODY; .GAMMA.4 HEAVY CHAIN HUMANIZED (1-453) (HOMO SAPIENS VH (IGHV2-70*11 (90%) (IGHD)-

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

732320

Created by admin on Sat Dec 16 13:30:15 UTC 2023 , Edited by admin on Sat Dec 16 13:30:15 UTC 2023

FDA ORPHAN DRUG

807821

Created by admin on Sat Dec 16 13:30:15 UTC 2023 , Edited by admin on Sat Dec 16 13:30:15 UTC 2023

Code System Code Type Description

USAN

HI-227

Created by admin on Sat Dec 16 13:30:15 UTC 2023 , Edited by admin on Sat Dec 16 13:30:15 UTC 2023

PRIMARY

NCI_THESAURUS

C155813

Created by admin on Sat Dec 16 13:30:15 UTC 2023 , Edited by admin on Sat Dec 16 13:30:15 UTC 2023

PRIMARY

INN

10953

Created by admin on Sat Dec 16 13:30:15 UTC 2023 , Edited by admin on Sat Dec 16 13:30:15 UTC 2023

PRIMARY

CAS

2155851-88-8

Created by admin on Sat Dec 16 13:30:15 UTC 2023 , Edited by admin on Sat Dec 16 13:30:15 UTC 2023

PRIMARY

FDA UNII

R96Z451BMC

Created by admin on Sat Dec 16 13:30:15 UTC 2023 , Edited by admin on Sat Dec 16 13:30:15 UTC 2023

PRIMARY

From	To
1_22	1_97
1_140	3_214
1_153	1_209
1_232	2_232
1_235	2_235
1_267	1_327
1_373	1_431
2_22	2_97
2_140	4_214
2_153	2_209
2_267	2_327
2_373	2_431
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_303
N	2_303

Related Record Type Details


					2VXO9I489U

MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR

TARGET -> INHIBITOR

Comments:

Prevents the binding of both colony stimulating factor 1 (CSF-1) and interleukin 34 (IL-34) to CSF-1R

Amount:

Related Record Type Details


					R96Z451BMC

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL