GSK-2256098

Investigational

CONC(=O)C1=CC=CC=C1NC2=CC(NC3=CC(C)=NN3C(C)C)=NC=C2Cl

InChIKey=BVAHPPKGOOJSPU-UHFFFAOYSA-N

InChI=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22-18)23-16-8-6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23,24)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Focal adhesion kinase 1 15 Target ID: CHEMBL2695 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25486573	Inhibitor 8297		15.0 nM [IC50]

PubMed

Title	Date	PubMed
A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells.	2014	25486573

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:35:56 GMT 2023` Edited by `admin` on `Sat Dec 16 08:35:56 GMT 2023`
Record UNII	R7O0O4110G
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

GSK-2256098

Common Name

English

GSK2256098 [WHO-DD]

Common Name

English

2-((5-CHLORO-2-((3-METHYL-1-(1-METHYLETHYL)-1H-PYRAZOL-5-YL)AMINO)-4-PYRIDINYL)AMINO)-N-METHOXYBENZAMIDE

Systematic Name

English

BENZAMIDE, 2-((5-CHLORO-2-((3-METHYL-1-(1-METHYLETHYL)-1H-PYRAZOL-5-YL)AMINO)-4-PYRIDINYL)AMINO)-N-METHOXY-

Systematic Name

English

Code System Code Type Description

SMS_ID

300000041354