| Stereochemistry | ABSOLUTE |
| Molecular Formula | C15H27N5O5 |
| Molecular Weight | 357.4054 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)NCCCCNC(N)=N
InChI
InChIKey=LTLYEAJONXGNFG-DCAQKATOSA-N
InChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10-,11-/m0/s1
| Molecular Formula | C15H27N5O5 |
| Molecular Weight | 357.4054 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
E-64 is an inhibitor of calpain and other cysteine proteases such as cathepsin B, cathepsin L, cathepsin H. The low toxic effects of the inhibitor, in addition to its effective mechanism of action, makes E-64 a potential template for drugs to treat diseases where high levels of a cysteine proteases are the primary cause. It was discovered, that this drug slowed the rate of formation of cataract in cultured rat lenses, but this study was discontinued.
