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Details

Stereochemistry ABSOLUTE
Molecular Formula C15H27N5O5
Molecular Weight 357.4054
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of E-64

SMILES

CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)NCCCCNC(N)=N

InChI

InChIKey=LTLYEAJONXGNFG-DCAQKATOSA-N
InChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10-,11-/m0/s1

HIDE SMILES / InChI

Molecular Formula C15H27N5O5
Molecular Weight 357.4054
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 3 / 3
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

E-64 is an inhibitor of calpain and other cysteine proteases such as cathepsin B, cathepsin L, cathepsin H. The low toxic effects of the inhibitor, in addition to its effective mechanism of action, makes E-64 a potential template for drugs to treat diseases where high levels of a cysteine proteases are the primary cause. It was discovered, that this drug slowed the rate of formation of cataract in cultured rat lenses, but this study was discontinued.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
in rats teratogenic effects: Wistar rats were injected with 10-30 mg/kg of E-64 intra-peritoneally on days 9 and 10 of gestation
Route of Administration: Intraperitoneal
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
R76F7856MV
Record Status Validated (UNII)
Record Version