Azirkitug

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 13:44:35 GMT 2025` Edited by `admin` on `Wed Apr 02 13:44:35 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	R6HJ7X69JZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

H-gamma1 heavy chain humanized (1-450) [VH (Homo sapiens IGHV3-73*01 (84.8%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT[8.10.11] (26-33.51-60.99-109)) (1-120) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14 (CH1 R120>K (217) (121-218), hinge 1

Preferred Name

English

Azirkitug

Official Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens CCR8 (C-C motif chemokine receptor 8, CKR-L1, CDw198)], humanized monoclonal antibody

Common Name

English

azirkitug [INN]

Common Name

English

Immunoglobulin G1, anti-(human CC chemokine receptor CCR8) (human-Rattus norvegicus monoclonal PR-1925514 ?1-chain), disulfide with human-Rattus norvegicus monoclonal PR-1925514 ?-chain, dimer

Common Name

English

Code System Code Type Description

FDA UNII

R6HJ7X69JZ

Created by admin on Wed Apr 02 13:44:35 GMT 2025 , Edited by admin on Wed Apr 02 13:44:35 GMT 2025

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CAS

2837169-12-5

Created by admin on Wed Apr 02 13:44:35 GMT 2025 , Edited by admin on Wed Apr 02 13:44:35 GMT 2025

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INN

12916

Created by admin on Wed Apr 02 13:44:35 GMT 2025 , Edited by admin on Wed Apr 02 13:44:35 GMT 2025

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NCI_THESAURUS

C206879

Created by admin on Wed Apr 02 13:44:35 GMT 2025 , Edited by admin on Wed Apr 02 13:44:35 GMT 2025

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SMS_ID

300000050790

Created by admin on Wed Apr 02 13:44:35 GMT 2025 , Edited by admin on Wed Apr 02 13:44:35 GMT 2025

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From	To
1_22	1_98
2_22	2_98
2_147	2_203
2_223	4_214
2_264	2_324
1_147	1_203
2_370	2_428
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_223	3_214
1_229	2_229
1_232	2_232
1_264	1_324
1_370	1_428

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					R6HJ7X69JZ

Azirkitug

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_450] [2_450]	C-TERMINUS			LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL