Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C16H33NO5.ClH |
| Molecular Weight | 355.898 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.COCCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
InChI
InChIKey=LQFACEKDJKFAIT-NUSSTLEHSA-N
InChI=1S/C16H33NO5.ClH/c1-22-10-8-6-4-2-3-5-7-9-17-11-14(19)16(21)15(20)13(17)12-18;/h13-16,18-21H,2-12H2,1H3;1H/t13-,14+,15-,16-;/m1./s1
| Molecular Formula | C16H33NO5 |
| Molecular Weight | 319.4369 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
The immunosugar N-9-methoxynonyldeoxynojirimycin (SP-187, UV-4B) is an inhibitor of both glucosidases I and II. In preclinical studies, it displayed inhibition of dengue and influenza virus infection. The compound developed by Emergent BioSolutions and evaluated in phase 1 clinical trials on healthy subjects.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Imino sugars that are less toxic but more potent as antivirals, in vitro, compared with N-n-nonyl DNJ. | 2002 Sep |
|
| An iminosugar with potent inhibition of dengue virus infection in vivo. | 2013 Apr |
|
| The Iminosugar UV-4 is a Broad Inhibitor of Influenza A and B Viruses ex Vivo and in Mice. | 2016 Mar 7 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:00:13 GMT 2023
by
admin
on
Sat Dec 16 11:00:13 GMT 2023
|
| Record UNII |
R3Y2198MRP
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Code | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
FDA ORPHAN DRUG |
442714
Created by
admin on Sat Dec 16 11:00:13 GMT 2023 , Edited by admin on Sat Dec 16 11:00:13 GMT 2023
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
R3Y2198MRP
Created by
admin on Sat Dec 16 11:00:13 GMT 2023 , Edited by admin on Sat Dec 16 11:00:13 GMT 2023
|
PRIMARY | |||
|
1333144-07-2
Created by
admin on Sat Dec 16 11:00:13 GMT 2023 , Edited by admin on Sat Dec 16 11:00:13 GMT 2023
|
PRIMARY | |||
|
73425534
Created by
admin on Sat Dec 16 11:00:13 GMT 2023 , Edited by admin on Sat Dec 16 11:00:13 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
PARENT -> SALT/SOLVATE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |