Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C16H33NO5.ClH |
| Molecular Weight | 355.898 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.COCCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
InChI
InChIKey=LQFACEKDJKFAIT-NUSSTLEHSA-N
InChI=1S/C16H33NO5.ClH/c1-22-10-8-6-4-2-3-5-7-9-17-11-14(19)16(21)15(20)13(17)12-18;/h13-16,18-21H,2-12H2,1H3;1H/t13-,14+,15-,16-;/m1./s1
| Molecular Formula | C16H33NO5 |
| Molecular Weight | 319.4369 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
The immunosugar N-9-methoxynonyldeoxynojirimycin (SP-187, UV-4B) is an inhibitor of both glucosidases I and II. In preclinical studies, it displayed inhibition of dengue and influenza virus infection. The compound developed by Emergent BioSolutions and evaluated in phase 1 clinical trials on healthy subjects.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The Iminosugar UV-4 is a Broad Inhibitor of Influenza A and B Viruses ex Vivo and in Mice. | 2016-03-07 |
|
| In vivo therapeutic protection against influenza A (H1N1) oseltamivir-sensitive and resistant viruses by the iminosugar UV-4. | 2015 |
|
| An iminosugar with potent inhibition of dengue virus infection in vivo. | 2013-04 |
|
| Imino sugars that are less toxic but more potent as antivirals, in vitro, compared with N-n-nonyl DNJ. | 2002-09 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 23:34:02 GMT 2025
by
admin
on
Mon Mar 31 23:34:02 GMT 2025
|
| Record UNII |
R3Y2198MRP
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| Record Status |
Validated (UNII)
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| Record Version |
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| Name | Type | Language | ||
|---|---|---|---|---|
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Common Name | English | ||
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Preferred Name | English | ||
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Systematic Name | English |
| Classification Tree | Code System | Code | ||
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FDA ORPHAN DRUG |
442714
Created by
admin on Mon Mar 31 23:34:02 GMT 2025 , Edited by admin on Mon Mar 31 23:34:02 GMT 2025
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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R3Y2198MRP
Created by
admin on Mon Mar 31 23:34:02 GMT 2025 , Edited by admin on Mon Mar 31 23:34:02 GMT 2025
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PRIMARY | |||
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1333144-07-2
Created by
admin on Mon Mar 31 23:34:02 GMT 2025 , Edited by admin on Mon Mar 31 23:34:02 GMT 2025
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PRIMARY | |||
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73425534
Created by
admin on Mon Mar 31 23:34:02 GMT 2025 , Edited by admin on Mon Mar 31 23:34:02 GMT 2025
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PRIMARY |
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PARENT -> SALT/SOLVATE |
| Related Record | Type | Details | ||
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ACTIVE MOIETY |