Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C7H13NO2 |
| Molecular Weight | 143.1836 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(O)CNC(=O)C(C)=C
InChI
InChIKey=OKPYIWASQZGASP-UHFFFAOYSA-N
InChI=1S/C7H13NO2/c1-5(2)7(10)8-4-6(3)9/h6,9H,1,4H2,2-3H3,(H,8,10)
| Molecular Formula | C7H13NO2 |
| Molecular Weight | 143.1836 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| N-(2-Hydroxypropyl)methacrylamide-based polymer conjugates with pH-controlled activation of doxorubicin for cell-specific or passive tumour targeting. Synthesis by RAFT polymerisation and physicochemical characterisation. | 2010-11-20 |
|
| HPMA-RGD hydrogels seeded with mesenchymal stem cells improve functional outcome in chronic spinal cord injury. | 2010-10 |
|
| 72/74As-labeling of HPMA based polymers for long-term in vivo PET imaging. | 2010-09-15 |
|
| Synthesis and in vitro evaluation of defined HPMA folate conjugates: influence of aggregation on folate receptor (FR) mediated cellular uptake. | 2010-09-13 |
|
| Photopolymerized thermosensitive poly(HPMAlactate)-PEG-based hydrogels: effect of network design on mechanical properties, degradation, and release behavior. | 2010-08-09 |
|
| Pharmacokinetic and biodistribution studies of N-(2-hydroxypropyl)methacrylamide copolymer-dexamethasone conjugates in adjuvant-induced arthritis rat model. | 2010-08-02 |
|
| Synergistic action of doxorubicin bound to the polymeric carrier based on N-(2-hydroxypropyl)methacrylamide copolymers through an amide or hydrazone bond. | 2010-08-02 |
|
| Copolymerization behavior of N-(2-hydroxypropyl)methacrylamide and a methacrylated coiled-coil peptide derivative. | 2010-07-12 |
|
| Langmuir-Blodgett films of biocompatible poly(HPMA)-block-poly(lauryl methacrylate) and poly(HPMA)-random-poly(lauryl methacrylate): influence of polymer structure on membrane formation and stability. | 2010-04-20 |
|
| Intracellular delivery of a proapoptotic peptide via conjugation to a RAFT synthesized endosomolytic polymer. | 2010-04-05 |
|
| Endocytic uptake of a large array of HPMA copolymers: Elucidation into the dependence on the physicochemical characteristics. | 2010-04-02 |
|
| Water-soluble polymer-drug conjugates for combination chemotherapy against visceral leishmaniasis. | 2010-04-01 |
|
| HPMA Copolymers: 30 Years of Advances. Issue Dedicated to Prof. Jindrich Kopecek on the Occasion of his 70th Birthday. | 2010-02-17 |
|
| Molecular imaging of HPMA copolymers: visualizing drug delivery in cell, mouse and man. | 2010-02-17 |
|
| HPMA copolymers for masking and retargeting of therapeutic viruses. | 2010-02-17 |
|
| HPMA copolymers: 30 years of advances. | 2010-02-17 |
|
| HPMA copolymers for modulating cellular signaling and overcoming multidrug resistance. | 2010-02-17 |
|
| Do HPMA copolymer conjugates have a future as clinically useful nanomedicines? A critical overview of current status and future opportunities. | 2010-02-17 |
|
| Micelles based on HPMA copolymers. | 2010-02-17 |
|
| HPMA copolymer-cyclic RGD conjugates for tumor targeting. | 2010-02-17 |
|
| Improving the efficacy of combined modality anticancer therapy using HPMA copolymer-based nanomedicine formulations. | 2010-02-17 |
|
| Structural and chemical aspects of HPMA copolymers as drug carriers. | 2010-02-17 |
|
| HPMA copolymers: origins, early developments, present, and future. | 2010-02-17 |
|
| Immunogenicity and immunomodulatory properties of HPMA-based polymers. | 2010-02-17 |
|
| Beyond oncology--application of HPMA copolymers in non-cancerous diseases. | 2010-02-17 |
|
| Rational design of targeted cancer therapeutics through the multiconjugation of folate and cleavable siRNA to RAFT-synthesized (HPMA-s-APMA) copolymers. | 2010-02-08 |
|
| Multivalent benzoboroxole functionalized polymers as gp120 glycan targeted microbicide entry inhibitors. | 2010-02-01 |
|
| HPMA-copolymer conjugates targeted to tumor endothelium using synthetic oligopeptides. | 2009-12 |
|
| [Synthesis and biological activity of complexes of sulfonate-containing polyanions and gentamycin]. | 2009-11-26 |
|
| Development of biomaterial scaffold for nerve tissue engineering: Biomaterial mediated neural regeneration. | 2009-11-25 |
|
| HPMA copolymer conjugates with reduced anti-CD20 antibody for cell-specific drug targeting. I. Synthesis and in vitro evaluation of binding efficacy and cytostatic activity. | 2009-11-16 |
|
| Development of HPMA copolymer-anticancer conjugates: clinical experience and lessons learnt. | 2009-11-12 |
|
| Clinical experience with anthracycline antibiotics-HPMA copolymer-human immunoglobulin conjugates. | 2009-11-12 |
|
| Thermoresponsive, hydrolytically degradable polymer micelles intended for radionuclide delivery. | 2009-10-08 |
|
| The uptake of N-(2-hydroxypropyl)-methacrylamide based homo, random and block copolymers by human multi-drug resistant breast adenocarcinoma cells. | 2009-10 |
|
| Biodistribution of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer drug delivery. | 2009-09-12 |
|
| Self-assembled hydrogels from poly[N-(2-hydroxypropyl)methacrylamide] grafted with beta-sheet peptides. | 2009-08-10 |
|
| Radioactive labeling of defined HPMA-based polymeric structures using [18F]FETos for in vivo imaging by positron emission tomography. | 2009-07-13 |
|
| Enhanced cytotoxicity of a polymer-drug conjugate with triple payload of paclitaxel. | 2009-07-01 |
|
| Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers. | 2009-07 |
|
| Evaluation of pharmacokinetics of bioreducible gene delivery vectors by real-time PCR. | 2009-07 |
|
| HPMA-based polymer conjugates with drug combination. | 2009-06-28 |
|
| Cyclic RGD-targeting of reversibly stabilized DNA nanoparticles enhances cell uptake and transfection in vitro. | 2009-06 |
|
| Targetable HPMA copolymer-aminohexylgeldanamycin conjugates for prostate cancer therapy. | 2009-06 |
|
| Dextrin-trypsin and ST-HPMA-trypsin conjugates: enzyme activity, autolysis and thermal stability. | 2009-05-21 |
|
| Facile synthesis of multivalent folate-block copolymer conjugates via aqueous RAFT polymerization: targeted delivery of siRNA and subsequent gene suppression. | 2009-04-13 |
|
| Targeting bone metastases with a bispecific anticancer and antiangiogenic polymer-alendronate-taxane conjugate. | 2009 |
|
| Transporter molecules influence the gene expression in HeLa cells. | 2009 |
|
| [In vitro release study, in vivo evaluation of biodistribution and antitumor activity of HPMA copolymer-5-fluorouracil conjugates]. | 2008-11 |
|
| N-(2-Hydroxylpropyl)-Methacrylamide-Attached Doxorubicin Induces Cytotoxicity to Prostate Cancer Cell Line DU145. | 2008 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:38:29 GMT 2025
by
admin
on
Mon Mar 31 22:38:29 GMT 2025
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| Record UNII |
R3F262Z4E0
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| Record Status |
Validated (UNII)
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| Record Version |
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R3F262Z4E0
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38622
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N-(2-Hydroxypropyl) methacrylamide
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21442-01-3
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DTXSID30944024
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