trans-Clopenthixol is a typical antipsychotic drug of the thioxanthene class. Clopenthixol is composed of a mixture of cis-clopenthixol and trans-clopenthixol. The two isomers do not differ in several pharmacological properties, for instance, anti-noradrenergic effect. However, cis-clopenthixol possesses anti-dopaminergic effects, while trans-Clopenthixol not. Cis-Clopenthixol indicated for the management of the manifestations of schizophrenia and other mental illnesses with disturbances in thinking, emotional reactions and behavior.
Approval Year
PubMed
Title | Date | PubMed |
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The bucco-linguo-masticatory syndrome as a side-effect of neuroleptics therapy. | 1967 |
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Prolonged oculogyric crisis on addition of nifedipine to neuroleptic medication regime. | 1987 Jan |
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Zuclopenthixol and haloperidol/levomepromazine in the treatment of elderly patients with symptoms of aggressiveness and agitation: a double-blind, multi-centre study. | 1989 |
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Zuclopenthixol, a combined dopamine D1/D2 antagonist, versus haloperidol, a dopamine D2 antagonist, in tardive dyskinesia. | 1991 Dec |
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[acute dystonias in combined abuse of cocaine and neuroleptics]. | 1994 Nov 26 |
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Effect of some psychotropic drugs and a barbiturate on mycoplasmas. | 2000 Apr |
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Clozapine and weight gain. | 2001 May |
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Long term results of unilateral posteroventral pallidotomy for antipsychotic drug induced tardive dyskinesia. | 2005 Jul |
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[Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations]. | 2006 Jun |
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Fatal exertional heat stroke in a patient receiving zuclopenthixol, quetiapine and benztropine. | 2007 Fall |
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Severe laryngeal dystonia in a patient receiving zuclopenthixol "Acuphase" and fluoxetine. | 2010 Apr |
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Simultaneous determination of 25 common pharmaceuticals in whole blood using ultra-performance liquid chromatography-tandem mass spectrometry. | 2012 Sep |
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Comparative analysis of anti-toxoplasmic activity of antipsychotic drugs and valproate. | 2014 Mar |
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Paradoxical severe agitation induced by add-on high-doses quetiapine in schizo-affective disorder. | 2014 May 15 |
Patents
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