Trovocabtagene Autoleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 19:55:26 GMT 2023` Edited by `admin` on `Sat Dec 16 19:55:26 GMT 2023`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE ATTENUATED GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	BLOOD
Fraction Material Type	CELL
Fraction Name	CD4+ and CD8+ enriched T lymphocytes
Record UNII	R2U3SU5R9H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Trovocabtagene Autoleucel

Official Name

English

Autologous T lymphocytes obtained from peripheral blood mononuclear cells by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector encoding a chimeric antigen receptor (CAR) targeting human B cell maturation antigen (BCMA)

Common Name

English

trovocabtagene autoleucel [INN]

Common Name

English

Code System Code Type Description

FDA UNII

R2U3SU5R9H

Created by admin on Sat Dec 16 19:55:26 GMT 2023 , Edited by admin on Sat Dec 16 19:55:26 GMT 2023

PRIMARY

INN

12557

Created by admin on Sat Dec 16 19:55:26 GMT 2023 , Edited by admin on Sat Dec 16 19:55:26 GMT 2023

PRIMARY

NCI_THESAURUS

C199019

Created by admin on Sat Dec 16 19:55:26 GMT 2023 , Edited by admin on Sat Dec 16 19:55:26 GMT 2023

PRIMARY

Related Record Type Details


					P050J5FWC5

INTERFERON GAMMA

CONSTITUENT ALWAYS PRESENT -> PARENT

Comments:

The T lymphocytes secrete interferon gamma (IFN-γ) following co-culture with BCMA-expressing cells

Amount:


					PK6VHJAIBD

TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 17

TARGET->CYTOTOXIC T-CELL

Amount:

Related Record Type Details


					R2U3SU5R9H

Trovocabtagene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
LENTIVIRAL TRANSFECTION	TRANSFECTION	BIOLOGICAL	Trovocabtagene autoleucel lentiviral vector	NE4J8ZD6Q4
CULTURE	ACTIVATOR	BIOLOGICAL	UNSPECIFIED SUBSTANCE	4e4ac683
CULTURE	EXPANSION	BIOLOGICAL	HUMAN INTERLEUKIN-2	FNO32LO217

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					Trovocabtagene autoleucel expressed anti-BCMA chimeric antigen receptor (CAR)	V49W4QP5VN
INSERTED GENE EXPRESSION VECTOR					Trovocabtagene autoleucel transgene insert	S6G6VN6UWY