U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 19:55:26 GMT 2023
Edited
by admin
on Sat Dec 16 19:55:26 GMT 2023
Source Materials Class ORGANISM
Source Materials Type AUTOLOGOUS HUMAN
Source Materials State LIVE ATTENUATED GENETICALLY MODIFIED
Source Materials Parent
Part BLOOD
Fraction Material Type CELL
Fraction Name CD4+ and CD8+ enriched T lymphocytes
Record UNII
R2U3SU5R9H
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Trovocabtagene Autoleucel
INN  
Official Name English
Autologous T lymphocytes obtained from peripheral blood mononuclear cells by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector encoding a chimeric antigen receptor (CAR) targeting human B cell maturation antigen (BCMA)
Common Name English
trovocabtagene autoleucel [INN]
Common Name English
Code System Code Type Description
FDA UNII
R2U3SU5R9H
Created by admin on Sat Dec 16 19:55:26 GMT 2023 , Edited by admin on Sat Dec 16 19:55:26 GMT 2023
PRIMARY
INN
12557
Created by admin on Sat Dec 16 19:55:26 GMT 2023 , Edited by admin on Sat Dec 16 19:55:26 GMT 2023
PRIMARY
NCI_THESAURUS
C199019
Created by admin on Sat Dec 16 19:55:26 GMT 2023 , Edited by admin on Sat Dec 16 19:55:26 GMT 2023
PRIMARY
Related Record Type Details
CONSTITUENT ALWAYS PRESENT -> PARENT
The T lymphocytes secrete interferon gamma (IFN-γ) following co-culture with BCMA-expressing cells
TARGET->CYTOTOXIC T-CELL
Related Record Type Details
ACTIVE MOIETY

Agent Modifications

Modification Process Modification Role Modification Type Amount Fragment Name Fragment ID
LENTIVIRAL TRANSFECTION TRANSFECTION BIOLOGICAL Trovocabtagene autoleucel lentiviral vector NE4J8ZD6Q4
CULTURE ACTIVATOR BIOLOGICAL UNSPECIFIED SUBSTANCE 4e4ac683
CULTURE EXPANSION BIOLOGICAL HUMAN INTERLEUKIN-2 FNO32LO217

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
VECTOR EXPRESSED PROTEIN Trovocabtagene autoleucel expressed anti-BCMA chimeric antigen receptor (CAR) V49W4QP5VN
INSERTED GENE EXPRESSION VECTOR Trovocabtagene autoleucel transgene insert S6G6VN6UWY