Trovocabtagene Autoleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 17:44:54 GMT 2025` Edited by `admin` on `Wed Apr 02 17:44:54 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE ATTENUATED GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Material Type	cell
Fraction Name	cd4+ and cd8+ enriched t lymphocytes
Record UNII	R2U3SU5R9H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Trovocabtagene Autoleucel

Official Name

English

Autologous T lymphocytes obtained from peripheral blood mononuclear cells by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector encoding a chimeric antigen receptor (CAR) targeting human B cell maturation antigen (BCMA)

Preferred Name

English

trovocabtagene autoleucel [INN]

Common Name

English

Code System Code Type Description

SMS_ID

300000053749

Created by admin on Wed Apr 02 17:44:54 GMT 2025 , Edited by admin on Wed Apr 02 17:44:54 GMT 2025

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FDA UNII

R2U3SU5R9H

Created by admin on Wed Apr 02 17:44:54 GMT 2025 , Edited by admin on Wed Apr 02 17:44:54 GMT 2025

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INN

12557

Created by admin on Wed Apr 02 17:44:54 GMT 2025 , Edited by admin on Wed Apr 02 17:44:54 GMT 2025

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NCI_THESAURUS

C199019

Created by admin on Wed Apr 02 17:44:54 GMT 2025 , Edited by admin on Wed Apr 02 17:44:54 GMT 2025

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Related Record Type Details


					P050J5FWC5

INTERFERON GAMMA

CONSTITUENT ALWAYS PRESENT -> PARENT

Comments:

The T lymphocytes secrete interferon gamma (IFN-?) following co-culture with BCMA-expressing cells

Amount:


					PK6VHJAIBD

TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 17

TARGET->CYTOTOXIC T-CELL

Amount:

Related Record Type Details


					R2U3SU5R9H

Trovocabtagene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
LENTIVIRAL TRANSFECTION	TRANSFECTION	BIOLOGICAL	Trovocabtagene autoleucel lentiviral vector	NE4J8ZD6Q4
CULTURE	ACTIVATOR	BIOLOGICAL	ANTI-CD3/ANTI-CD28 4.5 MICRON MAGNETIC BEADS	PA28ZKP50M
CULTURE	EXPANSION	BIOLOGICAL	HUMAN INTERLEUKIN-2	FNO32LO217

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					Trovocabtagene autoleucel expressed anti-BCMA chimeric antigen receptor (CAR)	V49W4QP5VN
INSERTED GENE EXPRESSION VECTOR					Trovocabtagene autoleucel transgene insert	S6G6VN6UWY