BMS-433796

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H20F2N4O4
Molecular Weight	430.4047
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@H](NC(=O)[C@@H](O)C1=CC(F)=CC(F)=C1)C(=O)N[C@H]2C3=CC=CC=C3C=NN(C)C2=O

InChI

InChIKey=HXEHCCYOTHDPPI-NBHSMZAVSA-N

InChI=1S/C21H20F2N4O4/c1-11(25-20(30)18(28)13-7-14(22)9-15(23)8-13)19(29)26-17-16-6-4-3-5-12(16)10-24-27(2)21(17)31/h3-11,17-18,28H,1-2H3,(H,25,30)(H,26,29)/t11-,17-,18-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C21H20F2N4O4
Molecular Weight	430.4047
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology.	2007-12-21	17932033
Ex vivo occupancy of gamma-secretase inhibitors correlates with brain beta-amyloid peptide reduction in Tg2576 mice.	2007-10	17640949
Discovery of (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S,Z)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide (BMS-433796): a gamma-secretase inhibitor with Abeta lowering activity in a transgenic mouse model of Alzheimer's disease.	2007-07-15	17502137

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:38:22 GMT 2025` Edited by `admin` on `Mon Mar 31 22:38:22 GMT 2025`
Record UNII	R1E8M783K2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BENZENEACETAMIDE, N-((1S)-2-(((5S)-4,5-DIHYDRO-3-METHYL-4-OXO-3H-2,3-BENZODIAZEPIN-5-YL)AMINO)-1-METHYL-2-OXOETHYL)-3,5-DIFLUORO-.ALPHA.-HYDROXY-, (.ALPHA.S)-

Preferred Name

English

BMS-433796

Common Name

English

Code System Code Type Description

PUBCHEM

23656215

Created by admin on Mon Mar 31 22:38:22 GMT 2025 , Edited by admin on Mon Mar 31 22:38:22 GMT 2025

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FDA UNII

R1E8M783K2

Created by admin on Mon Mar 31 22:38:22 GMT 2025 , Edited by admin on Mon Mar 31 22:38:22 GMT 2025

PRIMARY

CAS

935525-13-6

Created by admin on Mon Mar 31 22:38:22 GMT 2025 , Edited by admin on Mon Mar 31 22:38:22 GMT 2025

PRIMARY

Related Record Type Details


					R1E8M783K2

BMS-433796

ACTIVE MOIETY