URIDINE PHOSPHATE DIPOTASSIUM

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C9H12N2O12P2.2K
Molecular Weight	480.3419
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of URIDINE PHOSPHATE DIPOTASSIUM

Structure Search

SMILES

[K+].[K+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP(O)([O-])=O)N2C=CC(=O)NC2=O

InChI

InChIKey=QLYHPAJMTFPEHP-WFIJOQBCSA-L

InChI=1S/C9H14N2O12P2.2K/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18);;/q;2*+1/p-2/t4-,6-,7-,8-;;/m1../s1

HIDE SMILES / InChI

Molecular Formula	K
Molecular Weight	39.0983
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C9H12N2O12P2
Molecular Weight	402.1453
Charge	-2
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
CDP-choline pathway 3 Target ID: GO:0006657 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16126180	Activator 1430

PubMed

Title	Date	PubMed
Inhibition of herpes simplex virus DNA polymerase by purine ribonucleoside monophosphates.	1986 Feb 5	3003073
Antibody-nucleic acid complexes. Oligo(dG)n and -(dT)n specificities associated with anti-DNA antibodies from autoimmune MRL mice.	1989 Dec 26	2559771
Comparison between tryptophan methoxyindole and kynurenine metabolic pathways in normal and preterm neonates and in neonates with acute fetal distress.	1998 Jul	9703384
Design, synthesis and structural analysis of novel bent DNAs containing cyclic uridylate dimer analogues.	2006	17150818
RNA recognition and cleavage by the SARS coronavirus endoribonuclease.	2006 Aug 11	16828802
KREPA4, an RNA binding protein essential for editosome integrity and survival of Trypanosoma brucei.	2006 May	16601201
Molecular dynamics DFT:B3LYP study of guanosinetriphosphate conversion into guanosinemonophosphate upon Mg2+ chelation of alpha and beta phosphate oxygens of the triphosphate tail.	2006 May 14	16751877
RNA-protein interactions in assembled editing complexes in trypanosomes.	2007	17662838
The role of Ureaplasma nucleoside monophosphate kinases in the synthesis of nucleoside triphosphates.	2007 Apr	17355283
Modulation of mRNA stability as a novel therapeutic approach.	2007 Apr	17320967
The RNA-binding protein HuD binds acetylcholinesterase mRNA in neurons and regulates its expression after axotomy.	2007 Jan 17	17234598
Differences in glutamic acid and 5'-ribonucleotide contents between flesh and pulp of tomatoes and the relationship with umami taste.	2007 Jul 11	17567148
Identification of quorum sensing-related regulons in Vibrio vulnificus by two-dimensional gel electrophoresis and differentially displayed reverse transcriptase PCR.	2007 Jun	17506728
RNA-editing-associated protein 1 null mutant reveals link to mitochondrial RNA stability.	2007 Jun	17416633
Expression of RNA virus proteins by RNA polymerase II dependent expression plasmids is hindered at multiple steps.	2007 Jun 5	17550613
Sendai virus RNA polymerase scanning for mRNA start sites at gene junctions.	2007 Jun 5	17300823
Structural and enzymatic investigation of the Sulfolobus solfataricus uridylate kinase shows competitive UTP inhibition and the lack of GTP stimulation.	2007 Mar 13	17297917
Functional and structural insights revealed by molecular dynamics simulations of an essential RNA editing ligase in Trypanosoma brucei.	2007 Nov 14	18060084
Turkey coronavirus non-structure protein NSP15--an endoribonuclease.	2008	19023218
Identification of a bacterial-like HslVU protease in the mitochondria of Trypanosoma brucei and its role in mitochondrial DNA replication.	2008 Apr 18	18421378
Comparative phylogenomics and multi-gene cluster analyses of the Citrus Huanglongbing (HLB)-associated bacterium Candidatus Liberibacter.	2008 Aug 28	18755041
Reversible sialylation: synthesis of cytidine 5'-monophospho-N-acetylneuraminic acid from cytidine 5'-monophosphate with alpha2,3-sialyl O-glycan-, glycolipid-, and macromolecule-based donors yields diverse sialylated products.	2008 Jan 8	18067323
Structural analysis reveals conformational plasticity in the recognition of RNA 3' ends by the human La protein.	2008 Jun	18547518
Trypanosoma brucei RNA editing protein TbMP42 (band VI) is crucial for the endonucleolytic cleavages but not the subsequent steps of U-deletion and U-insertion.	2008 Jun	18441050
Complete sequence and analysis of the mitochondrial genome of Hemiselmis andersenii CCMP644 (Cryptophyceae).	2008 May 12	18474103
The binary protein interactome of Treponema pallidum--the syphilis spirochete.	2008 May 28	18509523
The crystal structure of UMP kinase from Bacillus anthracis (BA1797) reveals an allosteric nucleotide-binding site.	2008 Sep 19	18625239
Dietary intake of selected B vitamins in relation to risk of major cancers in women.	2008 Sep 2	18665162
Improving the quality of infant sleep through the inclusion at supper of cereals enriched with tryptophan, adenosine-5'-phosphate, and uridine-5'-phosphate.	2009 Dec	19925721
Toward understanding the conformational dynamics of RNA ligation.	2009 Feb 3	19133737
Unique GTP-binding pocket and allostery of uridylate kinase from a gram-negative phytopathogenic bacterium.	2009 Jan 30	19059268
Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH).	2009 Jul 1	19570206
Post-transcriptional regulation of gene expression in plants during abiotic stress.	2009 Jul 10	19742130
The complex regulation of HIC (Human I-mfa domain containing protein) expression.	2009 Jul 7	19582149
Expression and subcellular localization of kinetoplast-associated proteins in the different developmental stages of Trypanosoma cruzi.	2009 Jun 4	19497120
TbPIF5 is a Trypanosoma brucei mitochondrial DNA helicase involved in processing of minicircle Okazaki fragments.	2009 Sep	19779567
The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase.	2009 Sep 10	20157568
Non-redundant functions of two proline dehydrogenase isoforms in Arabidopsis.	2010 Apr 19	20403182
The Alveolate Perkinsus marinus: biological insights from EST gene discovery.	2010 Apr 7	20374649
The impact of mRNA structure on guide RNA targeting in kinetoplastid RNA editing.	2010 Aug 17	20808932
Novel naphthalene-based inhibitors of Trypanosoma brucei RNA editing ligase 1.	2010 Aug 24	20808768
3'-coterminal subgenomic RNAs and putative cis-acting elements of Grapevine leafroll-associated virus 3 reveals 'unique' features of gene expression strategy in the genus Ampelovirus.	2010 Aug 3	20682046
Flavin-dependent thymidylate synthase: a novel pathway towards thymine.	2010 Jan 1	19643076
The macroscopic rate of nucleic acid translocation by hepatitis C virus helicase NS3h is dependent on both sugar and base moieties.	2010 Jul 16	20451531
Comparison of koala LPCoLN and human strains of Chlamydia pneumoniae highlights extended genetic diversity in the species.	2010 Jul 21	20646324
RNA virus replication complexes.	2010 Jul 22	20661480
The 3'-terminal sequence of Bamboo mosaic virus minus-strand RNA interacts with RNA-dependent RNA polymerase and initiates plus-strand RNA synthesis.	2010 Mar	20447270
Identifying essential genes in bacterial metabolic networks with machine learning methods.	2010 May 3	20438628
Evaluation of reference genes for quantitative reverse-transcription polymerase chain reaction normalization in infected tomato plants.	2010 Nov	21029324
Mutational analysis of the C-terminal FATC domain of Saccharomyces cerevisiae Tra1.	2010 Oct	20635087

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:27:01 GMT 2023` Edited by `admin` on `Sat Dec 16 01:27:01 GMT 2023`
Record UNII	R1547KG6JX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

URIDINE PHOSPHATE DIPOTASSIUM

Systematic Name

English

Uridine phosphate dipotassium [WHO-DD]

Common Name

English

URIDINE 5'-(TRIHYDROGEN DIPHOSPHATE), DIPOTASSIUM SALT

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID70243088