Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | 10C4H6N2S4.9Mn.Zn |
| Molecular Weight | 2663.49 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Mn++].[Mn++].[Mn++].[Mn++].[Mn++].[Mn++].[Mn++].[Mn++].[Mn++].[Zn++].[S-]C(=S)NCCNC([S-])=S.[S-]C(=S)NCCNC([S-])=S.[S-]C(=S)NCCNC([S-])=S.[S-]C(=S)NCCNC([S-])=S.[S-]C(=S)NCCNC([S-])=S.[S-]C(=S)NCCNC([S-])=S.[S-]C(=S)NCCNC([S-])=S.[S-]C(=S)NCCNC([S-])=S.[S-]C(=S)NCCNC([S-])=S.[S-]C(=S)NCCNC([S-])=S
InChI
InChIKey=UYNPYIFEUKYCHF-UHFFFAOYSA-A
InChI=1S/10C4H8N2S4.9Mn.Zn/c10*7-3(8)5-1-2-6-4(9)10;;;;;;;;;;/h10*1-2H2,(H2,5,7,8)(H2,6,9,10);;;;;;;;;;/q;;;;;;;;;;10*+2/p-20
| Molecular Formula | Mn |
| Molecular Weight | 54.938045 |
| Charge | 2 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C4H8N2S4 |
| Molecular Weight | 212.38 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | Zn |
| Molecular Weight | 65.409 |
| Charge | 2 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Mancozeb is a broad spectrum fungicide
used in agriculture, professional turf management, and horticulture. Mancozeb is a member of the
ethylene bisdithiocarbamate (EBDC) group of fungicides. Mancozeb itself is not fungicidal and can effectively be considered a profungicide which, when exposed to water, breaks down to release ethylene bisisothiocyanate sulfide (EBIS), which is then converted via the action of UV light into ethylene bisisothiocyanate (EBI). Both EBIS and EBI are believed to be the active toxicants and are thought to interfere with enzymes containing sulphydryl groups. This fatal disruption of core enzymatic processes is postulated to inhibit or interfere with at least six different biochemical processes within the fungal cell cytoplasm and mitochondria. Mancozeb should be regarded as a suspected developmental hazard and a presumed reproductive hazard in humans.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Studies of teratogenic effects of the dithiocarbamates maneb, mancozeb, and propineb. | 1976 Oct |
|
| Pellagroid dermatitis from mancozeb with vitiligo. | 1985 Aug |
|
| Teratogenic evaluation of mancozeb in the rat following inhalation exposure. | 1986 Jun 30 |
|
| Subacute toxicological examination of Dithane M-45. | 1989 Aug |
|
| Analysis of chromosome aberrations and sister-chromatid exchanges in peripheral blood lymphocytes of workers with occupational exposure to the mancozeb-containing fungicide Novozir Mn80. | 1989 Oct |
|
| Influence of mancozeb on mitogenically responsive lipids in rat cerebrum and liver. | 1991 Oct |
|
| Antimutagenic efficacy of higher doses of vitamin C. | 1993 Jan |
|
| [Allergic diseases caused by pesticides: 3 case reports]. | 1994 Jul-Aug |
|
| Ameliorating effect of vitamin C on murine sperm toxicity induced by three pesticides (endosulfan, phosphamidon and mancozeb). | 1996 Jan |
|
| Occupational allergic contact dermatitis and airborne contact dermatitis from 5 fungicides in a vineyard worker. Cross-reactions between fungicides of the dithiocarbamate group? | 1996 May |
|
| Immunomodulatory effects of occupational exposure to mancozeb. | 1996 Nov-Dec |
|
| Photoallergic contact dermatitis from mancozeb, an agricultural fungicide. | 1996 Sep |
|
| Induction of gonadal toxicity to male rats after chronic exposure to mancozeb. | 1997 |
|
| Studies on rat thyroid after oral administration of mancozeb: morphological and biochemical evaluations. | 1997 Nov-Dec |
|
| Assessment of toxicological effects of mancozeb in male rats after chronic exposure. | 1999 Jun |
|
| Interaction of Dithane M-45 (mancozeb) and lead acetate during a teratogenicity test in rats. | 2000 |
|
| Induction of gonadal toxicity to female rats after chronic exposure to mancozeb. | 2001 Jul |
|
| Different responses of biochemical markers in frogs (Rana ridibunda) from urban and rural wetlands to the effect of carbamate fungicide. | 2008 Sep |
|
| Pesticide use and cutaneous melanoma in pesticide applicators in the agricultural heath study. | 2010 Jun |
|
| Reversible Parkinsonism after accidental oral intake of mancozeb. | 2011 Feb 15 |
|
| Neoplastic alterations induced in mammalian skin following mancozeb exposure using in vivo and in vitro models. | 2011 Mar |
|
| Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets. | 2011 Mar 28 |
|
| Exposure to glyphosate- and/or Mn/Zn-ethylene-bis-dithiocarbamate-containing pesticides leads to degeneration of γ-aminobutyric acid and dopamine neurons in Caenorhabditis elegans. | 2012 Apr |
|
| Ethylene bisdithiocarbamate pesticides cause cytotoxicity in transformed and normal human colon cells. | 2012 Sep |
|
| Mancozeb-induced behavioral deficits precede structural neural degeneration. | 2013 Jan |
|
| The effect of perinatal exposure to ethinyl oestradiol or a mixture of endocrine disrupting pesticides on kisspeptin neurons in the rat hypothalamus. | 2013 Jul |
Sample Use Guides
Using an in vitro model of reproductive toxicity, comprising parietal granulosa cells (GCs) from mouse antral follicles cultured with increasing concentrations of mancozeb (0.001-1 µg/ml). Morphometric analysis evidenced a reduction of mitochondrial length in GCs exposed to mancozeb 0.01-1 µg/ml and a dose-dependent increase of vacuole dimension.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:54:43 GMT 2025
by
admin
on
Mon Mar 31 18:54:43 GMT 2025
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| Record UNII |
R0HY55EB9E
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
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| Classification Tree | Code System | Code | ||
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EPA PESTICIDE CODE |
14504
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admin on Mon Mar 31 18:54:43 GMT 2025 , Edited by admin on Mon Mar 31 18:54:43 GMT 2025
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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mancozeb
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m7050
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DTXSID0034695
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6792
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76957227
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8018-01-7
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C011453
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R0HY55EB9E
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C013099
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52492
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PARENT -> SALT/SOLVATE |
