Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | 10C4H6N2S4.9Mn.Zn |
| Molecular Weight | 2663.49 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Mn++].[Mn++].[Mn++].[Mn++].[Mn++].[Mn++].[Mn++].[Mn++].[Mn++].[Zn++].[S-]C(=S)NCCNC([S-])=S.[S-]C(=S)NCCNC([S-])=S.[S-]C(=S)NCCNC([S-])=S.[S-]C(=S)NCCNC([S-])=S.[S-]C(=S)NCCNC([S-])=S.[S-]C(=S)NCCNC([S-])=S.[S-]C(=S)NCCNC([S-])=S.[S-]C(=S)NCCNC([S-])=S.[S-]C(=S)NCCNC([S-])=S.[S-]C(=S)NCCNC([S-])=S
InChI
InChIKey=UYNPYIFEUKYCHF-UHFFFAOYSA-A
InChI=1S/10C4H8N2S4.9Mn.Zn/c10*7-3(8)5-1-2-6-4(9)10;;;;;;;;;;/h10*1-2H2,(H2,5,7,8)(H2,6,9,10);;;;;;;;;;/q;;;;;;;;;;10*+2/p-20
| Molecular Formula | C4H8N2S4 |
| Molecular Weight | 212.38 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | Zn |
| Molecular Weight | 65.409 |
| Charge | 2 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | Mn |
| Molecular Weight | 54.938 |
| Charge | 2 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Mancozeb is a broad spectrum fungicide
used in agriculture, professional turf management, and horticulture. Mancozeb is a member of the
ethylene bisdithiocarbamate (EBDC) group of fungicides. Mancozeb itself is not fungicidal and can effectively be considered a profungicide which, when exposed to water, breaks down to release ethylene bisisothiocyanate sulfide (EBIS), which is then converted via the action of UV light into ethylene bisisothiocyanate (EBI). Both EBIS and EBI are believed to be the active toxicants and are thought to interfere with enzymes containing sulphydryl groups. This fatal disruption of core enzymatic processes is postulated to inhibit or interfere with at least six different biochemical processes within the fungal cell cytoplasm and mitochondria. Mancozeb should be regarded as a suspected developmental hazard and a presumed reproductive hazard in humans.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Subacute toxicological examination of Dithane M-45. | 1989 Aug |
|
| Analysis of chromosome aberrations and sister-chromatid exchanges in peripheral blood lymphocytes of workers with occupational exposure to the mancozeb-containing fungicide Novozir Mn80. | 1989 Oct |
|
| Status of ornithine decarboxylase activity and DNA synthesis in mancozeb-exposed mouse skin. | 1992 Jan |
|
| [Allergic diseases caused by pesticides: 3 case reports]. | 1994 Jul-Aug |
|
| Ameliorating effect of vitamin C on murine sperm toxicity induced by three pesticides (endosulfan, phosphamidon and mancozeb). | 1996 Jan |
|
| Occupational allergic contact dermatitis and airborne contact dermatitis from 5 fungicides in a vineyard worker. Cross-reactions between fungicides of the dithiocarbamate group? | 1996 May |
|
| Interaction of Dithane M-45 (mancozeb) and lead acetate during a teratogenicity test in rats. | 2000 |
|
| One-generation reproduction toxicity study of mancozeb and lead acetate. | 2001 |
|
| Transplacental carcinogenic potential of the carbamate fungicide mancozeb. | 2001 |
|
| Anti-implantation effect of a carbamate fungicide mancozeb in albino mice. | 2002 Apr |
|
| Results of long-term experimental studies on the carcinogenicity of ethylene-bis-dithiocarbamate (Mancozeb) in rats. | 2002 Dec |
|
| Temporal effects of mancozeb on testes, accessory reproductive organs and biochemical constituents in albino mice. | 2003 Dec |
|
| Pesticide use and menstrual cycle characteristics among premenopausal women in the Agricultural Health Study. | 2004 Dec 15 |
|
| Different responses of biochemical markers in frogs (Rana ridibunda) from urban and rural wetlands to the effect of carbamate fungicide. | 2008 Sep |
|
| Pesticide use and cutaneous melanoma in pesticide applicators in the agricultural heath study. | 2010 Jun |
|
| Exposure to Mn/Zn ethylene-bis-dithiocarbamate and glyphosate pesticides leads to neurodegeneration in Caenorhabditis elegans. | 2011 Jun |
|
| Environmental impact on vascular development predicted by high-throughput screening. | 2011 Nov |
|
| The fungicide mancozeb induces toxic effects on mammalian granulosa cells. | 2012 Apr 15 |
|
| Mancozeb-induced genotoxicity and apoptosis in cultured human lymphocytes. | 2012 Jun 6 |
|
| Ethylene bisdithiocarbamate pesticides cause cytotoxicity in transformed and normal human colon cells. | 2012 Sep |
|
| Mancozeb-induced behavioral deficits precede structural neural degeneration. | 2013 Jan |
Sample Use Guides
Using an in vitro model of reproductive toxicity, comprising parietal granulosa cells (GCs) from mouse antral follicles cultured with increasing concentrations of mancozeb (0.001-1 µg/ml). Morphometric analysis evidenced a reduction of mitochondrial length in GCs exposed to mancozeb 0.01-1 µg/ml and a dose-dependent increase of vacuole dimension.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:50:27 UTC 2023
by
admin
on
Fri Dec 15 17:50:27 UTC 2023
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| Record UNII |
R0HY55EB9E
|
| Record Status |
Validated (UNII)
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| Record Version |
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| Classification Tree | Code System | Code | ||
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EPA PESTICIDE CODE |
14504
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admin on Fri Dec 15 17:50:27 UTC 2023 , Edited by admin on Fri Dec 15 17:50:27 UTC 2023
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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mancozeb
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m7050
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PRIMARY | Merck Index | ||
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6792
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76957227
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8018-01-7
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C011453
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R0HY55EB9E
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C013099
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52492
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| Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
